Evidence map›Paper›PMID 40893098›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2025

Evaluating the cost-effectiveness of the Prostate Cancer Patient Empowerment Program A comprehensive health economic analysis from a randomized controlled trial.

Alexandra Nuyens, Gabriela Ilie, Ricardo A Rendon, Ross J Mason, Mohammad Hajizadeh, Prosper Senyo Koto, Martha Foley, Andrea Kokorovic, Nikhilesh Patil, David Bowes and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Investing in prostate cancer survivorship.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexandra NuyensDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
Gabriela IlieDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
Ricardo A RendonDepartment of Urology, Dalhousie University, Halifax, NS, Canada.
Ross J MasonDepartment of Urology, Dalhousie University, Halifax, NS, Canada.
Mohammad HajizadehSchool of Health Administration, Faculty of Health, Dalhousie University, Halifax, NS, Canada.
Prosper Senyo KotoResearch Innovation and Discovery, Nova Scotia Health, Halifax, NS, Canada.
Martha FoleyDepartment of Urology, Dalhousie University, Halifax, NS, Canada.
Andrea KokorovicDepartment of Urology, Dalhousie University, Halifax, NS, Canada.
Nikhilesh PatilDepartment of Radiation Oncology, Dalhousie University, Halifax, NS, Canada.
David BowesDepartment of Radiation Oncology, Dalhousie University, Halifax, NS, Canada.
Greg BaillyDepartment of Urology, Dalhousie University, Halifax, NS, Canada.
Derek WilkeDepartment of Radiation Oncology, Dalhousie University, Halifax, NS, Canada.
Cody MacDonaldDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
Robert David Harold RutledgeDepartment of Radiation Oncology, Dalhousie University, Halifax, NS, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to evaluate the cost-effectiveness of the Prostate Cancer Patient Empowerment Program (PC-PEP), a six-month comprehensive intervention designed to enhance psychological well-being and reduce healthcare expenditures among prostate cancer patients.

methodsIn a crossover randomized clinical trial of 128 men aged 50-82 years scheduled for curative prostate cancer surgery or radiotherapy (± hormone treatment), 66 men received the PC-PEP intervention immediately, while 62 were randomized to a waitlist control arm and received standard care for six months before receiving PC-PEP. The intervention included daily activities targeting physical fitness, pelvic floor training, stress management, intimacy, social support, and dietary guidance. Cost-effectiveness was assessed from a healthcare payer perspective using billing data from Nova Scotia's Medical Services Insurance (MSI) and self-reported outcomes. Incremental cost-effectiveness ratios (ICERs) and cost-effectiveness acceptability curves (CEACs) were calculated using bootstrapped samples. Psychological distress was assessed with the Kessler Psychological Distress Scale (K10), while quality-adjusted life years (QALYs) were estimated from SF-6D utility scores.

resultsPC-PEP resulted in cost savings of $411.53 CAD per patient at six months, with a 30% reduction in clinically significant psychological distress and a QALY gain of 0.013. At 12 months, savings increased to $660.89 CAD per patient, preventing 31% of distress cases and yielding a QALY gain of 0.034. These outcomes demonstrate that PC-PEP is a dominant intervention, achieving both improved clinical outcomes and reduced healthcare expenditures.

conclusionsPC-PEP is a dominant, cost-effective strategy that significantly improves psychological well-being while lowering healthcare costs. Early implementation following prostate cancer diagnosis is strongly recommended to maximize both clinical and economic benefits.

Identifiers

PMID40893098
PMCPMC12705157

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.