Evidence map›Paper›PMID 40893304›Full record

ArticleACS omega2025

Hydrogel-Mediated Sustained Delivery of Corneal Epithelial Extracellular Vesicles: A Strategy for Enhanced Corneal Regeneration.

Jenny Rosenquist Lybecker, Ann Van de Ven, Ken Braesch-Andersen, David Juriga, Norein Norein, Per Hansson, Ayan Samanta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jenny Rosenquist LybeckerMacromolecular Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 538, 751 21 Uppsala, Sweden.
Ann Van de VenMacromolecular Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 538, 751 21 Uppsala, Sweden.
Ken Braesch-AndersenMacromolecular Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 538, 751 21 Uppsala, Sweden.
David JurigaPharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Uppsala University, Box 574, 751 23 Uppsala, Sweden.
Norein NoreinMacromolecular Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 538, 751 21 Uppsala, Sweden.
Per HanssonPharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Uppsala University, Box 574, 751 23 Uppsala, Sweden.ORCID https://orcid.org/0000-0002-0895-1180
Ayan SamantaMacromolecular Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 538, 751 21 Uppsala, Sweden.ORCID https://orcid.org/0000-0002-6977-0711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) derived from corneal epithelial cells have shown great promise in promoting corneal wound healing and stromal regeneration, but they face challenges with rapid clearance from the eye. This study addresses these challenges by developing a biocompatible collagen-hydrogel sustained delivery system. We successfully isolated, purified, and characterized corneal epithelial EVs (CE-EVs), assessed their efficacy in corneal epithelial healing in vitro, and demonstrated their sustained delivery over 10 days followed by an on-demand release through enzymatic degradation of the hydrogel, which mimics the in vivo scenario. To develop a microscale understanding of the EV diffusion inside the hydrogel matrix, we probed the hydrogel network with several model compounds and nanoparticles by using advanced confocal microscopy analyses, followed by fitting our results to established diffusion models. Our findings suggest this innovative approach offers a safe and effective strategy to promote corneal wound healing. This technology has the potential to revolutionize corneal injury treatment and improve patient outcomes. Moreover, the possibility to tailor EV-release kinetics broadens the scope of EV research in clinical practices, as varying short- and long-term release profiles will be required for diverse medical applications.

Identifiers

PMID40893304
PMCPMC12391988

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.