ArticleQuantitative imaging in medicine and surgery2025
Noninvasive assessment of pulmonary vascular resistance: a synergistic approach using computed tomography pulmonary angiography and echocardiography in pulmonary hypertension.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pulmonary vascular resistance (PVR) is essential in managing pulmonary hypertension (PH) and has prompted the search for noninvasive assessment techniques. This study investigates the integration of morphological parameters from computed tomography pulmonary angiography (CTPA) and functional parameters from transthoracic echocardiography (TTE) to develop a noninvasive method for evaluating PVR in patients with PH. Methods: Data from PH patients who underwent CTPA, TTE, and right heart catheterization (RHC) were analyzed retrospectively. The Cobb angle, defined as the angle between the spine and interventricular septum, was calculated by CTPA. It is assumed that thorax geometry, pericardial morphology, and body surface area (BSA) are factors influencing the Cobb angle measurement, and these factors were adjusted for in the analysis. Multiple linear regression was performed to evaluate the multivariate ability to predict PVR. Multivariate Cox regression analysis assessed the prognostic value of parameters in predicting hospitalization for heart failure. Results: In total, 78 patients meeting the criteria were enrolled. Among the TTE parameters, the right ventricular outflow tract acceleration time (RVOT-AT) demonstrated the best goodness-of-fit to PVR (R Conclusions: The integration of BSA-adjusted morphological markers from CTPA with hemodynamic parameters derived from TTE provides a promising noninvasive method for predicting PVR and demonstrates significant prognostic value in evaluating heart failure in PH patients.
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