ArticleQuantitative imaging in medicine and surgery2025
An exploratory study of the diffusion tensor imaging analysis along perivascular spaces (DTI-ALPS) index combined with quantitative analysis of choroid plexus volume and perivascular spaces in different cognitive stages of cerebral small vessel disease.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DTI-ALPS index and cognitive impairment in cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- The role of glymphatic-related structural and functional imaging biomarkers in the pathological progression of Alzheimer's disease: a multimodal imaging-based study.Quantitative imaging in medicine and surgery · 2026Article
- Investigation of type 2 diabetes mellitus and mild cognitive impairment: a study based on diffusion tensor imaging analysis along the perivascular space and peak width of skeletonized mean diffusivity.Quantitative imaging in medicine and surgery · 2026Article
- Altered cerebrospinal fluid-based clearance mechanisms in aging autistic adults.Research square · 2026Article
- Choroid plexus enlargement is associated with poor functional status in cerebral small vessel disease via reduced DTI-ALPS index: a 5T MRI study.Quantitative imaging in medicine and surgery · 2026Article
- Tissue-specific diffusion abnormalities and localized free-water reductions in hypertension despite no detectable group difference in the DTI-ALPS index.Frontiers in medicine · 2026Article
- Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease.Frontiers in neurology · 2026Article
- Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition.Frontiers in aging neuroscience · 2025Article
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11 authors.
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Abstract
Background: Cerebral small vessel disease (CSVD) is a major contributor to cognitive impairment and dementia. Growing evidence suggests that impaired perivascular clearance plays a pivotal role in CSVD pathogenesis, yet non-invasive biomarkers for early cognitive decline remain limited. This study aimed to explore the diagnostic value of the diffusion tensor imaging analysis along perivascular spaces (DTI-ALPS) index, enlarged perivascular spaces (EPVS) numbers/volume, and choroid plexus volume (CPV) across different cognitive stages of CSVD. Methods: We retrospectively analyzed data from 102 CSVD patients [33 CSVD-cognitive normal (CSVD-CN); 39 CSVD-mild cognitive impairment (CSVD-MCI); 30 vascular dementia (VaD)] and 29 normal controls (NCs). Quantitative measurements of the DTI-ALPS index, EPVS numbers/volume, and CPV were obtained. Correlations with Montreal Cognitive Assessment (MoCA) scores and diagnostic performance were also evaluated. Results: Progressive DTI-ALPS index reduction (NCs: 1.50±0.19, CSVD-CN: 1.41±0.17, CSVD-MCI: 1.34±0.16, VaD: 1.33±0.17; P<0.001, r=0.36) and increases in basal ganglia (BG)-EPVS numbers {NCs: 4 [3, 6], CSVD-CN: 14 [10, 17], CSVD-MCI: 16 [12, 25], VaD: 22 [13, 31]; P<0.001, r=-0.45} and CPV {NCs: 1.35 [1.02, 1.65] cm Conclusions: Combining the DTI-ALPS index, BG-EPVS numbers, and CPV may enhance early diagnosis and subtype differentiation in CSVD-related cognitive impairment, supporting targeted interventions.
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