ReviewBiomaterials and biosystems2025
The emerging role of biomaterial applications in cerebral lymphatic surgical interventions: A narrative review.
Review in Biomaterials and biosystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pathophysiologic similarities between autism spectrum disorder and Alzheimer's disease: therapeutic possibilities.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebral lymphatic system plays a critical role in central nervous system (CNS) homeostasis through fluid regulation, toxin clearance, and immune modulation. Recent discoveries in the glial-lymphatic (glymphatic) and meningeal lymphatic systems have demonstrated their involvement in a spectrum of CNS pathologies such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), traumatic brain injury (TBI), stroke, and cancers. This review summarizes current understanding of the cerebral lymphatic system's mechanisms and their contribution to CNS health. Furthermore, we emphasize the linkage of lymphatic dysfunction and the pathogenesis of neurodegenerative and neuroinflammatory etiologies. Lymphatic alterations such as deep cervical lymph node (DCLN) manipulation have been shown to increase function, reduce toxin accumulation and improve disease. Other techniques like supermicrosurgical interventions of lymphaticovenular (lymphovenous) anastomosis and lymphatic reconstruction have recently demonstrated therapeutic benefits. Novel approaches of supermicrosurgical techniques, such as cervical shunting to decompress lymphatic systems (CSULS), have displayed promising cognitive improvements in AD patients. We additionally explore the role of biomaterials in improving interventional outcomes and their potential to be applied to lymphatic surgical developments. Despite their widespread applications in surgical practice, the use of biomaterials in cerebral lymphatic reconstruction remains unexplored. This review discusses the potential benefits of integrating biomaterials into emerging lymphatic interventions to improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.