Evidence map›Paper›PMID 40893802›Full record

ArticleIJID regions2025

The association between previous SARS-CoV-2 infection and incidence of stroke.

Naveed Akhtar, Hiam Chemaitelly, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Uy, Muzna I Lone, Abdul-Badi Abou-Samra, Laith J Abu-Raddad, Adeel A Butt

Abstract read
In one paragraph

Article in IJID regions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naveed AkhtarNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Hiam ChemaitellyInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
Saadat KamranNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Sujatha JosephNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Deborah MorganNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Ryan UyNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Muzna I LoneCorporate Quality and Patient Safety Department, Hamad Medical Corporation, Doha, Qatar.
Abdul-Badi Abou-SamraCorporate Quality and Patient Safety Department, Hamad Medical Corporation, Doha, Qatar.
Laith J Abu-RaddadInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
Adeel A ButtDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To define the association between prior SARS-CoV-2 infection and incidence of stroke. Methods: We conducted a case-control study combining the Qatar stroke database and the Qatar National COVID-19 databases. Cases with stroke diagnosis were matched 1:1 on demographics, comorbidities, and vaccination status to controls who tested negative for SARS-CoV-2 during the same week. Adjusted odds ratios (aORs) comparing the odds of previous documented SARS-CoV-2 infection in cases relative to controls were estimated using conditional logistic regression. Results: Among 1640 matched pairs, 234 (14.3%) previous SARS-CoV-2 infections were recorded among cases and 399 (24.3%) among controls. The aOR (95% confidence interval [CI]) for the association of previous infection with stroke was 0.48 (0.40-0.58). Subgroup analyses revealed aORs of comparable magnitude among those aged 40-59 years and ≥60 years and those with or without coexisting conditions. Those unvaccinated (aOR 0.43; 95% CI 0.29-0.62), vaccinated with two doses (aOR 0.46; 95% CI 0.35-0.60), and vaccinated with three or more doses (aOR 0.63; 95% CI 0.42-0.96) all exhibited similar protective association of previous infection with stroke. Conclusions: Individuals with previous COVID-19 infection are less likely to develop stroke; this finding is not explained by demographic characteristics, comorbidities, or previous vaccination status.

Indexed as

COVID-19SARS-CoV-2StrokeVaccination

Identifiers

PMID40893802
PMCPMC12391267

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.