ArticleFrontiers in medicine2025
Association between creatinine clearance and mortality in Chinese patients with osteoporotic fractures: a retrospective cohort study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Creatinine clearance (CCR) is a vital biomarker for evaluating renal function, indicating the efficiency of the kidneys in filtering blood waste. However, the link between CCR and mortality in hospitalized patients with osteoporotic fractures (OPFs) remains unclear. The increasing prevalence of OPFs in elderly populations, coupled with known complications of renal dysfunction, underscores the critical importance of understanding this relationship. This study aimed to investigate the association between CCR levels and mortality in a cohort of hospitalized patients with OPFs, with the goal of establishing evidence-based guidelines for risk stratification and management strategies. Methods: A retrospective cohort study analyzed data from 3,177 patients hospitalized with OPFs between 6 December 2018 and 31 December 2023. A multivariate Cox regression analysis was used to evaluate the relationship between CCR and mortality while adjusting for potential confounding variables, including laboratory parameters, clinical characteristics, and lifestyle factors. Subgroup analyses, smoothed curve fitting with threshold analyses, Kaplan-Meier curves, and sensitivity analyses were performed. Results: A linear correlation between CCR and mortality was observed, with each 1-point increment in CCR correlating with a 2% reduction in mortality risk (hazard ratio (HR) = 0.98; 95% confidence interval (CI): 0.97, 0.98; Conclusion: This study demonstrated a significant association between CCR and mortality among hospitalized patients with OPFs, validating CCR as a valuable prognostic marker for assessing mortality risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.