ArticleFrontiers in medicine2025
Comprehensive pre- and in-hospital near-infrared-spectroscopy (NIRS) monitoring after return of spontaneous circulation predicts neurological outcome following out-of-hospital cardiac arrest: a prospective observational study and literature review.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Relationship Between Cerebral Oximetry and Outcomes in Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis.Critical care explorations · 2026Pooled it
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An increase in regional cerebral oxygen saturation (rSO2) levels during advanced life support in patients with out-of-hospital cardiac arrest (OHCA) is associated with return of spontaneous circulation (ROSC) and can predict neurological outcome. Data from the post-ROSC phase are scarce but may predict clinical outcomes as well. Methods: For this prospective observational study, we measured rSO2 via near-infrared spectroscopy (NIRS) in patients after ROSC following OHCA in both the pre- and in-hospital setting for up to 72 h. Patients were followed up for their post-ROSC treatment and outcomes. NIRS values were then compared between patients with favorable and non-favorable neurological outcomes, and cutoff values were assessed via receiver operating characteristic (ROC) and Classification and Regression Trees (CART) analyses. In addition, a narrative review on the topic was performed. Results: Of the 27 included patients, 37% survived hospital discharge, and 26% showed favorable neurological outcomes (CPC 1 or 2). RSO2 was significantly higher in individuals with CPC 1/2 (67 [60-69] % vs. 59 [50-70] %; Conclusion: We identified a potential RSO2 cutoff measured via NIRS in the post-ROSC phase after OHCA to predict favorable neurological outcomes. Initial values and rising trends may be more useful for prognostication than prolonged ICU measurements. These findings are consistent with previous literature and should prompt both larger clinical trials and consideration of this technology by resuscitation societies.
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