ArticleFrontiers in medicine2025
Global, regional, and national burdens of endometriosis from 1990 to 2021: a trend analysis.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Targeting the Immune Network in Endometriosis: A Comprehensive Review of Pathogenesis, Immunomodulation, and Emerging Therapies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management.MedComm · 2026Review
- Epidemiology, Risk Factors, Diagnosis, and Comorbidities of Endometriosis: An Umbrella Review.Journal of clinical medicine · 2026Review
- Menstrual Effluent in the Pathogenesis and Diagnosis of Endometriosis-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Examining physical activity and menstrual cycle experiences among insufficiently active women: Project PACE protocol.Health psychology and behavioral medicine · 2026Article
- Associations between aggregate index of systemic inflammation and endometriosis risk utilizing logistic regression analysis.Frontiers in medicine · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehensive data on this issue are currently lacking. This study aimed to examine trends in the burden of endometriosis at the global, national, and regional levels. Methods: We collected detailed data on incidence numbers, disability-adjusted life years (DALYs), age-standardized incidence rate (ASIR), and age-standardized DALY rate (ASDR) for the period 1990-2021 from the GBD 2021 database. We calculated the estimated annual percentage changes (EAPCs) to quantify the temporal trends in the ASIR and ASDR of endometriosis and presented the global distribution of these trends. Results: The global incident cases of endometriosis were 3.45 million (95% uncertainty interval [UI] = 2.44 to 4.6), and DALYs were 2.05 million (95% UI = 1.20 to 3.13). The global ASIR decreased from 1990 to 2021 (EAPC = -1.01, 95% UI = -1.06 to -0.96), while the ASDR was similar (EAPC = -0.99, 95% UI = -1.04 to -0.95). The age groups with the highest global incidence and DALYs were 20-24 and 25-29 years. The highest 2021 ASIR and ASDR were both in Niger (77.33 per 100,000 individuals, 95% UI = 52.74 to 106.78; 61.45 per 100,000 individuals, 95% UI = 34.29 to 95.47) and in Oceania (77.71 per 100,000 individuals, 95% UI = 51.23 to 100.27; 45.24 per 100,000 individuals, 95% UI = 45.24 to 71.95). In 2021, the ASIR and ASDR were highest in the low sociodemographic index (SDI) region. We also found that the EAPC was negatively correlated with ASIR in 1990 ( Conclusion: The global burden of endometriosis remains substantial and has continued to rise across most countries, territories, and regions since the 1990s, underscoring the urgent need for targeted public health strategies and advancements in diagnosis and treatment to address this pervasive condition.
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