ArticleFrontiers in genetics2025
Shared genetic architecture between grip strength and cognitive function: insights from large-scale genome-wide cross-trait analysis.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Physical and cognitive decline are common in older individuals, and traits related to grip strength and cognitive function are used to assess the common genetic structure between the two and to identify common risk loci and genes as well as the genetic mechanisms involved. Methods: On the basis of large-scale genome-wide association study (GWAS) summary-level datasets, we observed genetic overlaps between grip strength and cognitive function, and cross-trait pleiotropic analysis was performed to detect shared pleiotropic loci and genes. A series of functional annotations and tissue-specific analyses were performed to determine the influence of pleiotropic genes. Heritance enrichment analysis was used to detect crucial immune cells and tissues. Finally, drug targets were explored via the SMR method. Results: This study highlighted genetic mechanisms shared between five types of cognitive function-related traits and grip strength. This study identified 20 novel SNP loci (P < 5 × 10 Conclusion: Overall, our results provide new insights into the genetics of cognitive function and grip strength and shed light on the underlying molecular mechanisms that may be involved.
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