Evidence map›Paper›PMID 40894129›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study.

Jose A Caparrós-Martín, Elizabeth Kicic-Starcevich, Patricia Agudelo-Romero, David G Hancock, Thomas Iosifidis, Yuliya V Karpievitch, David J Martino, Guicheng Zhang, Desiree T Silva, Anthony Bosco and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jose A Caparrós-MartínUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0003-1214-4952
Elizabeth Kicic-StarcevichWal-yan Respiratory Research Centre, The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia.
Patricia Agudelo-RomeroWal-yan Respiratory Research Centre, The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-3703-4111
David G HancockUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Thomas IosifidisUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Yuliya V KarpievitchWal-yan Respiratory Research Centre, The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0003-2586-3358
David J MartinoWal-yan Respiratory Research Centre, The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-6823-4696
Guicheng ZhangUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Desiree T SilvaUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Anthony BoscoAsthma and Airway Disease Research Center University of Arizona Tucson, Arizona.ORCID 0000-0002-4335-615X
Susan L PrescottUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Peter N LeSouëfUWA Medical School, UWA Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Anthony KicicWal-yan Respiratory Research Centre, The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-0008-9733
Stephen M StickDepartment of Sleep and Respiratory Medicine, Perth Children's Hospital, Perth, Western Australia, Australia.ORCID 0000-0002-5386-8482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early-life susceptibility to viral respiratory infections is associated with long-term respiratory morbidity in children. Currently, no reliable tools exist to predict susceptibility to these infections. Given its role in modulating pathogen virulence and airway inflammation, the endogenous microbiota represents a potential target for prevention. In this pilot study, we investigated whether distinct nasal microbial communities are associated with viral respiratory disease and respiratory phenotypes during the first year of life. Methods: We analyzed 90 nasal swabs from 55 infants enrolled in the AERIAL study, representing background samples collected at schedule visits (~4 months old) and samples from symptomatic episodes. Bacterial profiling was done blinded to clinical data via full-length Results: Nasal bacterial diversity was similar between background and symptomatic swabs, with community composition differences largely driven by inter-individual variation. In paired samples, symptomatic swabs showed reduced diversity but no change in bacterial load. Virus-bacteria interactions were observed in rhinovirus-positive swabs, but not in SARS-CoV-2-positive swabs. Two distinct bacterial endotypes were identified, enriched in either Conclusion: Our pilot data suggest that the nasal microbiota might influence wheezing outcomes in a sex-specific manner, highlighting the need for larger, longitudinal investigations.

Indexed as

nasal microbiotaORIGINSrespiratory epitheliaViral infection

Identifiers

PMID40894129
PMCPMC12393612

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.