ArticlemedRxiv : the preprint server for health sciences2025
A mega-analysis of low frequency resting-state measures in mood and psychosis-spectrum disorders.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Objective: Conduct a mega-analysis of two complementary measures of resting-state functional magnetic resonance imaging (rsfMRI) dynamics-amplitude of low-frequency fluctuation (ALFF) and low-frequency spectral entropy (lfSE)-in mood and psychosis-spectrum disorders to evaluate group differences and clinical symptom associations. Design: ALFF and lfSE were calculated at the node-level by filtering data from 0.01 Hz to 0.08 Hz, regressing demographic variables, and harmonizing sites. Group differences were assessed using the Wilcoxon signed test. Symptom associations were evaluated with Spearman's rho. Analyses were conducted at both whole-brain and network levels, with sensitivity analyses to evaluate the impact of frequency brands. Setting: Four independent open-source case-control datasets with resting-state functional magnetic resonance imaging were used: the Center for Biomedical Research Excellence, the Human Connectome Project for Early Psychosis, the Strategic Research Program for Brain Sciences, and the UCLA Consortium for Neuropsychiatric Phenomics. Participants: Included participants had a mood disorder (bipolar, dysthymia, or major depressive disorder, n=228, aged 38.31 ± 12.56 years), a psychosis-spectrum disorder (early psychosis, schizophrenia spectrum disorder, or mood disorder with psychotic symptoms, n=318, aged 29.8 ± 13.21 years), or a healthy control (n=535, aged 39.89 ± 15.3 years). Main outcomes and Measures: To identify group differences and symptom associations in mood and psychosis-spectrum disorders using ALFF and lfSE. Results: ALFF in psychosis-spectrum was significantly lower than mood disorders and controls (q's<0.001) at the whole-brain and network levels. lfSE in controls was significantly lower than both psychosis-spectrum and mood disorders at the whole-brain and network levels (q's<0.001). Whole-brain ALFF is positively associated with mood symptoms (rho=0.27, p<0.05). Whole-brain lfSE is negatively associated with positive (rho=-0.13, p<0.05) and mood (rho=-0.38, p<0.01) symptoms. A greater sensitivity of group differences and symptom associations to frequency ranges was observed in mood disorders. ALFF is sensitive to medication. Conclusions and Relevance: Widespread, global differences in ALFF and lfSE underly psychosis-spectrum and mood disorders. lfSE may be applicable for wider use in fMRI. Differences in spectral measures of brain dynamics may represent shared and distinct markers of mental health.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.