Evidence map›Paper›PMID 40894259›Full record

ArticleCell signaling2025

The role of circulating anti-aging αKlotho in cardiac aging.

Dong I Lee, Dao-Fu Dai

Abstract read
In one paragraph

Article in Cell signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dong I LeeDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dao-Fu DaiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore MD, USA.

Funding

Metabolic reprogramming and FGF21 signaling in kidney health and polycystic kidney diseasesR01DK133118 · NIDDK · UNIVERSITY OF IOWA · PI Dao-Fu Dai · 2022 to 2026
$2.0M
NIDDK NIH HHS R01 DK133118
6 · The paper itself

Abstract

Aging contributes significantly to the deterioration of cardiac function and increases the prevalence of heart failure, including those with reduced or preserved ejection fraction. Heart failure with preserved ejection fraction (HFpEF) is highly prevalent in the elderly population and it has become a leading cause of morbidity and mortality in this group. This commentary discusses the important findings and broader implications of the study by Daneshgar

Identifiers

PMID40894259
PMCPMC12395429

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.