ReviewInnovation in aging2025
The effect of physical interventions in older adults on inflammatory markers (IL-6, IL-10, CRP, TNF-α): an umbrella review of systematic reviews and meta-analyses.
Review in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Within-Day Timing of Concurrent Training Affects Inflammation and Body Composition in Young Adults With Obesity.Obesity (Silver Spring, Md.) · 2026Trial
- Immunofitness in the elderly: The role of vaccination in promoting healthy aging.Human vaccines & immunotherapeutics · 2026Review
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Physical Exercise and Gut Microbiota: Implications for Alzheimer's Disease in Experimental Models: A Systematic Review and Meta-Analysis.Journal of functional morphology and kinesiology · 2026Review
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
- Article
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults-A Narrative Review.Biomedicines · 2026Review
- Age-Dependent Differences in Exercise Response Among Healthy Women: Impact on Inflammation, Lipids Profile and Glucose.Biomedicines · 2026Article
- Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review.Clinical interventions in aging · 2026Review
- Aging and vaccines: impact of immunosenescence and inflammaging in vaccine response.Frontiers in aging · 2026Review
- Inflammaging and neurovascular unit dysfunction in cognitive ageing: mechanisms, biomarkers, and therapeutic opportunities.Frontiers in aging neuroscience · 2026Review
- Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in "moderate-intensity exercise".Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: The occurrence of chronic low-grade inflammation during aging, also referred to as " Research Design and Methods: Thirteen systematic reviews on the effects of long-term exercise on CRP, TNF-α, IL-6, and IL-10 in adults aged 60 years and older were selected from a systematic search in databases PubMed and Web of Science and were included in this umbrella review. Results: Overall, a variety of long-term exercise modalities were able to reduce levels of CRP in older adults. Moreover, most exercise interventions were also able to decrease TNF-α. Some studies showed that long-term exercise can diminish IL-6, but the results are less conclusive. The long-term effects of exercise on IL-10 were less described in the literature, with only two systematic reviews showing increases, decreases, or no effects. Discussion and Implications: Results obtained in this umbrella review show that different exercise modalities can decrease circulating pro-inflammatory parameters CRP, TNF-α, and IL-6 in older adults. More research is needed to appraise the effect of exercise interventions on IL-10 in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.