ArticleInternational journal of general medicine2025
Investigating the Therapeutic Effects of Bushen Huoxue Formula Combined with Aerobic Exercise on Reproductive Function in Obese Polycystic Ovary Syndrome: An Experimental Study Based on the Integration of Sports and Medicine.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the therapeutic effects of Bushen Huoxue Formula combined with aerobic exercise (COMB) on reproductive function in obese polycystic ovary syndrome (PCOS) mice. Methods: Seventy-six 3-week-old female C57BL/6JGpt mice were randomly divided into a control group (CON, Results: After 8 weeks of intervention, MET, BHF, AE, and COMB groups showed significant improvements in ovarian morphology, body weight, BFP, insulin resistance (HOMA-IR), and serum sex hormone levels (P<0.05). Compared with the BHF and AE groups, the COMB group demonstrated superior effects in reducing BFP, T levels, and HOMA-IR (P<0.05). All intervention groups showed higher pregnancy rates compared to the MOD group. Notably, the BHF, AE, and COMB groups exhibited lower abortion and embryo loss rates than the MET group. COMB group showed the most favorable pregnancy outcomes, including higher pregnancy rate, lower abortion and embryo absorption rates, and increased total number of embryos. Conclusion: The combined intervention of the COMB group demonstrated superior therapeutic effects on reproductive function in obese PCOS mice compared to the individual interventions of the BHF group or AE group, with a better safety profile. The integrated sports-medicine approach shows promising clinical potential.
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