Evidence map›Paper›PMID 40894864›Full record

ArticleiScience2025

An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum.

Arpan Parichha, Debarpita Datta, Amrita Singh, Ishita Talwar, Shreya Yadav, Mahima Bose, Varun Suresh, Špela Miroševič, Nina Žakelj, David Gosar and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07270549 (GAIN-CTNNB1), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07270549 phase1 / phase2recruitingnot on this map

GAIN-CTNNB1: A Phase I/II Open-Label Trial To Evaluate the Safety, Tolerability, and Preliminary Efficacy of Intracerebroventricular Administration of an AAV9 Based Gene Replacement Therapy in Paediatric Patients With CTNNB1 Neurodevelopmental Syndrome

TypeinterventionalSponsorCTNNB1 FoundationRan2025 to 2032Enrolled12ConditionsCTNNB1 Neurodevelopmental SyndromeArmsUrbagen gene addition therapy, Sirolimus, Methylprednisolone (Corticosteroid)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in neurology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arpan ParichhaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Debarpita DattaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Amrita SinghDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Ishita TalwarDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Shreya YadavCSIR- Institute for Genomics and Integrative Biology, Mathura Road, Sukhdev Vihar, New Delhi 110025, India.
Mahima BoseDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Varun SureshDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Špela MiroševičDepartment of Family Medicine, Medical Faculty Ljubljana, Ljubljana, Slovenia.
Nina ŽakeljDepartment of Pediatric Neurology, University Children's Hospital, University Medical Centre, Ljubljana, Bohoričeva 20, 1525 Ljubljana, Slovenia.
David GosarDepartment of Family Medicine, Medical Faculty Ljubljana, Ljubljana, Slovenia.
Damjan OsredkarDepartment of Pediatric Neurology, University Children's Hospital, University Medical Centre, Ljubljana, Bohoričeva 20, 1525 Ljubljana, Slovenia.
Shubha ToleDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The corpus callosum (CC) is a major nerve bundle that connects the two hemispheres of the brain. Dysgenesis of the CC is associated with neurodevelopmental disorders such as the CTNNB1 syndrome. We identified that five individuals carrying

Indexed as

Developmental neuroscienceMolecular neuroscienceNeuroscience

Identifiers

PMID40894864
PMCPMC12397918

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.