Evidence map›Paper›PMID 40894913›Full record

ArticleiScience2025

Depletion of all platelet integrins impacts hemostasis, thrombosis, and tumor metastasis.

Emily Janus-Bell, Cristina Liboni, Alexandra Yakusheva, Vincent Mittelheisser, Clarisse Mouriaux, Catherine Bourdon, Louis Bochler, Vincent Hyenne, Maria Garcia-Leon, Olivier Lefebvre and 2 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emily Janus-BellUniversité de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, 67065 Strasbourg, France.
Cristina LiboniTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Alexandra YakushevaUniversité de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, 67065 Strasbourg, France.
Vincent MittelheisserTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Clarisse MouriauxUniversité de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, 67065 Strasbourg, France.
Catherine BourdonUniversité de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, 67065 Strasbourg, France.
Louis BochlerTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Vincent HyenneTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Maria Garcia-LeonTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Olivier LefebvreTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Jacky G GoetzTumor Biomechanics, INSERM UMR_S1109, 67000 Strasbourg, France.
Pierre H ManginUniversité de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, 67065 Strasbourg, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet integrins, together with other platelet receptors, are known to control hemostasis and thrombosis but also metastatic progression. However, the impact of their exclusive but combined deficiency has never been tested in these processes. In a PF4Cre-β1

Indexed as

CancerCell biology

Identifiers

PMID40894913
PMCPMC12396298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.