Evidence map›Paper›PMID 40895099›Full record

ArticleFrontiers in neurology2025

Hippocampal dysmetabolism contributes to cognitive loss in autoimmune encephalitis and focal temporal epilepsy.

Olga Taraschenko, Lakshman Arcot Jayagopal, Audrina Mullane, Kyle Greenman, Matthew White, Hesham Ghonim, Shelley Lee, Rana Khalil Zabad, Tracy Jasinski, Mariano Uberti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Immune dysregulation and epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olga TaraschenkoDepartment of Neurological Sciences, Division of Epilepsy, University of Nebraska Medical Center, Omaha, NE, United States.
Lakshman Arcot JayagopalDepartment of Neurological Sciences, Division of Epilepsy, University of Nebraska Medical Center, Omaha, NE, United States.
Audrina MullaneDepartment of Neurological Sciences, Division of Neuropsychology, University of Nebraska Medical Center, Omaha, NE, United States.
Kyle GreenmanDepartment of Neurological Sciences, Division of Neuropsychology, University of Nebraska Medical Center, Omaha, NE, United States.
Matthew WhiteDepartment of Radiology, University of Nebraska Medical Center, Omaha, NE, United States.
Hesham GhonimDepartment of Neurological Sciences, Division of Epilepsy, University of Nebraska Medical Center, Omaha, NE, United States.
Shelley LeeDepartment of Neurological Sciences, Division of Epilepsy, University of Nebraska Medical Center, Omaha, NE, United States.
Rana Khalil ZabadDepartment of Neurological Sciences, Division of Neuroimmunology, University of Nebraska Medical Center, Omaha, NE, United States.
Tracy JasinskiDepartment of Neurological Sciences, Division of Epilepsy, University of Nebraska Medical Center, Omaha, NE, United States.
Mariano UbertiDepartment of Radiology, University of Nebraska Medical Center, Omaha, NE, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Autoimmune encephalitis (AE) is associated with severe cognitive disability. Brain metabolic dysfunction has been linked to encephalopathy in neurodegenerative disorders; however, its role in the development of cognitive loss in AE has not been studied. We hypothesized that cognitively impaired patients with AE will demonstrate altered brain metabolism and immune activation, and these measures will correlate with cognitive scores. Methods: The hippocampal and cortical metabolites related to neuronal integrity, oxidative metabolism, and glial activation were assessed using single-voxel proton magnetic resonance spectroscopy (1H-MRS) in patients with AE, non-lesional temporal lobe epilepsy (TLE) and control subjects. Metabolite levels were correlated with neuropsychological test scores. Results: We recruited patients with post-acute AE ( Conclusions: Although AE and TLE patients report similar cognitive issues, their hippocampal metabolic signatures differ. The disease-specific changes in the measures of hippocampal inflammation and neuronal integrity can inform trajectories for cognitive recovery and be targeted therapeutically.

Indexed as

autoimmune encephalitiscerebral metabolismcognitive lossmagnetic resonance spectroscopymemory deficitsmyo-inositoltemporal lobe epilepsy

Identifiers

PMID40895099
PMCPMC12391106

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.