ArticleFood science & nutrition2025
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Restless legs syndrome (RLS) has a multifactorial etiology, and current treatments are suboptimal. Micronutrients influence neuromuscular and dopaminergic function, yet their causal role in RLS is uncertain. This study aimed to investigate whether circulating micronutrients causally influence the risk of RLS by applying an integrated two-sample, bidirectional, and multivariable Mendelian Randomization (MR) strategy. Genetic instruments for micronutrient levels were obtained from genome-wide association studies (GWAS) in the IEU Open GWAS database. RLS outcome data were from the EU-RLS-GENE consortium (7248 cases, 19,802 controls of European ancestry). Single nucleotide polymorphisms significantly associated with each micronutrient (
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