Evidence map›Paper›PMID 40895156›Full record

ReviewFood production, processing and nutrition2025

Polyphenol-polysaccharide interactions: molecular mechanisms and potential applications in food systems - a comprehensive review.

Fereidoon Shahidi, Kerthika Devi Athiyappan

Abstract readReview
In one paragraph

Review in Food production, processing and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Article
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  11. Pilot Alkaline Extraction ofAntioxidants (Basel, Switzerland) · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. DualAntioxidants (Basel, Switzerland) · 2026
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Fereidoon ShahidiDepartment of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1C 5S7 Canada.
Kerthika Devi AthiyappanDepartment of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1C 5S7 Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyphenols, a major class of plant secondary metabolites, are well known for their diverse bioactive properties. It has also been established that polyphenols interact with other macromolecules, such as proteins, polysaccharides, and lipids in the food matrix. Among the primary metabolites of the plant, carbohydrates play a significant role. Polyphenols and polysaccharides form complexes upon interaction; this interaction could be through covalent or non-covalent bonds, such as electrostatic, hydrophobic, van der Waals forces, and hydrogen bonding. These polysaccharide-polyphenol complexes exhibit enhanced bioactivity and influence the digestibility of complex macronutrients (such as proteins and polysaccharides), as well as their biological efficacy, bioavailability, and stability. Despite their numerous benefits and potential applications, the underlying mechanisms of interaction and complex formation between polysaccharides and polyphenols, as well as the influence of their structural parameters, remain underexplored. This comprehensive review summarizes the basic molecular-level implications of polysaccharides and polyphenols, exploring their potential applications in the food industry, and provides a basic understanding of their occurrence in various food matrices, characteristics of both polyphenols and polysaccharides that influence their interaction mechanisms, and detection under laboratory conditions. The review aims to bridge the gap between the molecular-level understanding of the complex and the development of potential nutraceuticals and functional food ingredients based on polysaccharide-polyphenol complexation. Graphical Abstract:

Indexed as

Covalent interactionsNon-covalent interactionsPolyphenol-polysaccharide complexPolyphenolsPolysaccharides

Identifiers

PMID40895156
PMCPMC12397182

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.