Evidence map›Paper›PMID 40895239›Full record

ArticleBioactive materials2025

Lithium fine-tunes biodegradation of Zn-based implant to promote osseointegration through immunomodulation.

Danni Shen, Wei Qiao, Xiaoxue Xu, Shery L Y Chang, Thomas E Lockwood, Wenting Li, Parkarsh Kumar, Jie Shen, Jun Wu, Feihong Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Danni ShenSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Wei QiaoApplied Oral Sciences and Community Dental Cares, Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region of China.
Xiaoxue XuSchool of Biomedical Engineering, The University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Shery L Y ChangElectron Microscope Unit, Mark Wainwright Analytical Centre, University of New South Wales, NSW, 2052, Australia.
Thomas E LockwoodHyphenated Mass Spectrometry Laboratory, The University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Wenting LiSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Parkarsh KumarSchool of Materials Science and Engineering, University of New South Wales, NSW, 2052, Australia.
Jie ShenShenzhen Key Laboratory of Spine Surgery, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Jun WuShenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Feihong LiuShenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Kelvin W K YeungDepartment of Orthopedics and Traumatology, The University of Hong Kong, Hong Kong Special Administrative Region of China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration. In this study, we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process. During the early inflammatory phase, the controlled release of lithium ions (Li

Indexed as

BiodegradationBone regenerationOsseointegrationOsteoimmunomodulationZn-based alloy

Identifiers

PMID40895239
PMCPMC12391689

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.