ArticlePractical laboratory medicine2025
Prognostic value of baseline plasma D-dimer levels in sepsis: a prospective cohort study.
Article in Practical laboratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Physiological Phenotypes in Comatose ICU Patients: A Retrospective Multidimensional Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Explainable machine learning with routine biomarkers identifies culture-defined bacteremic urosepsis.Scientific reports · 2026Article
- Admission D-Dimer for Early Risk Stratification of in-Hospital Mortality in Adults with Non-HIV Cryptococcal Meningitis: A Retrospective Cohort Study.Infection and drug resistance · 2026Article
- Revisiting the Concept of DIC: A Phenotype-guided Framework for Modern Hemostatic Medicine.Juntendo medical journal · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Plasma D-dimer, a fibrin degradation product, reflects coagulation activation and is often elevated in critically ill patients. Its prognostic significance in sepsis, particularly for short-term outcomes, remains unclear. Methods: In this prospective cohort study, we enrolled 175 adult ICU patients with sepsis (Sepsis-3 criteria) from March 2024 to February 2025. Plasma D-dimer levels were measured at ICU admission and daily for five days. D-dimer levels were categorized into quartiles. The primary outcome was 30-day all-cause mortality; secondary outcome was in-hospital septic shock. Associations were analyzed using Cox regression, Kaplan-Meier analysis, and subgroup analysis. Results: Elevated admission D-dimer levels were significantly associated with increased risks of 30-day mortality and septic shock. Each 1 μg/mL increase in D-dimer was linked to a 6 % higher mortality risk (HR = 1.06; 95 % CI: 1.02-1.11; P = 0.008) and an 8 % higher septic shock risk (HR = 1.08; 95 % CI: 1.03-1.12; P < 0.001), after adjusting for confounders. Patients in the highest quartile had the worst outcomes. A significant interaction with serum amyloid A (SAA) was observed for mortality (P = 0.043), but not for septic shock. Conclusion: Baseline plasma D-dimer levels independently predict 30-day mortality and septic shock in sepsis. D-dimer may serve as a valuable early biomarker for risk stratification in sepsis management.
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