ReviewComputational and structural biotechnology journal2025
Computational modeling of drug-eluting balloons in peripheral artery disease: Mechanisms, optimization, and translational insights.
Review in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Drug-eluting balloons (DEBs) represent a promising alternative to stent-based interventions for peripheral artery disease (PAD), and their therapeutic efficacy is dependent on optimizing drug transfer, mechanical deployment, and vessel-wall interactions. This review synthesizes current advancements in computational modeling; systematically analyzes studies identified through comprehensive ScienceDirect, Scopus, and PubMed (2015-2025) searches; and selects them according to PRISMA guidelines. Key strategies, including computational fluid dynamics (CFD), finite element analysis (FEA), fluid-structure interaction (FSI), and machine learning (ML), are critically examined to elucidate how drug kinetics, coating stability, and mechanical stress govern therapeutic outcomes. CFD-based mass transfer models capture flow-driven drug dispersion and washout dynamics, whereas FEA links balloon mechanics, plaque morphology, and drug penetration efficiency. FSI frameworks provide insight into the coupled effects of wall deformation and hemodynamics, identifying high-risk regions of drug underdelivery. ML-driven surrogates and physics-informed neural networks (PINNs) enable real-time, patient-specific predictions with computational accelerations exceeding 600 × while maintaining less than 2 % deviation from high-fidelity solvers. Persistent challenges include anatomical simplifications, limited
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.