Evidence map›Paper›PMID 40895440›Full record

ArticleFrontiers in physiology2025

Three weeks of environmental enrichment enhance hepatic-muscular oxidative balance and decrease interleukin-6 levels in juvenile female C57BL/6 mice.

Débora Eduarda da Silva Fidélis, Matheus Santos de Sousa Fernandes, Tiago Lacerda Ramos, Clarice Beatriz Gonçalves Silva, Allifer Rosendo Perreira, Cássia Giselle de Olivera Nóbrega, Valdênia Maria Oliveira de Souza, Fatma Hilal Yagin, Yalin Aygun, Claudia Jacques Lagranha and 3 more

Abstract read
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In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Débora Eduarda da Silva FidélisKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Matheus Santos de Sousa FernandesKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Tiago Lacerda RamosKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Clarice Beatriz Gonçalves SilvaKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Allifer Rosendo PerreiraLaboratory of Biochemistry and Molecular Biology of Physical Exercise, Academic Center of Vitoria de Santo Antão, Federal University of Pernambuco, Vitoria de Santo Antão, Brazil.
Cássia Giselle de Olivera NóbregaKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Valdênia Maria Oliveira de SouzaKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Fatma Hilal YaginDepartment of Biostatistics, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye.
Yalin AygunDepartment of Sport Management, Faculty of Sport Sciences, Inonu University, Malatya, Türkiye.
Claudia Jacques LagranhaLaboratory of Biochemistry and Molecular Biology of Physical Exercise, Academic Center of Vitoria de Santo Antão, Federal University of Pernambuco, Vitoria de Santo Antão, Brazil.
Mariana Pinheiro FernandesLaboratory of Biochemistry and Molecular Biology of Physical Exercise, Academic Center of Vitoria de Santo Antão, Federal University of Pernambuco, Vitoria de Santo Antão, Brazil.
Reem M AlwhaibiDepartment of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Fabrício Oliveira SoutoKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The Environmental Enrichment (EE) promotes systemic responses through social, cognitive, sensory, and physical stimuli. However, its effects on hepatic and muscle oxidative balance, as well as on serum inflammation markers, remain unclear. Therefore, this study aimed to evaluate whether three weeks of EE could modulate hepatic and muscular oxidative balance and the inflammatory response in female C57BL/6 mice. Methods: The animals were divided into two groups: EE ( Results and discussion: EE significantly reduced body weight and malondialdehyde levels in the liver, soleus, and EDL muscles. Additionally, carbonyl levels decreased in the liver and soleus. Acute EE exposure enhanced enzymatic antioxidant activity (SOD, CAT, and GST) across all tissues, except for catalase activity in the EDL, which showed no significant difference between groups. Non-enzymatic defenses were improved, with reduced oxidized glutathione (GSSG) levels in the liver and soleus. Furthermore, EE increased the REDOX status in the liver and EDL. Sulfhydryl levels increased only in the liver. Finally, serum cytokine analysis revealed a significant reduction only in IL-6 levels. These findings suggest that three weeks of EE can modulate hepatic and muscular oxidative balance, as well as serum IL-6 levels, in juvenile female mice.

Indexed as

and metabolismcytokinesenzymatic activityinflammationoxidative stress

Identifiers

PMID40895440
PMCPMC12390971

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.