Evidence map›Paper›PMID 40895469›Full record

ArticleFrontiers in microbiology2025

The role of HIV-1 Gag and genomic RNA interactions in virion assembly.

Takaaki Koma, Bao Quoc Le, Khanh Quoc Tran, Naoya Doi, Tomoyuki Kondo, Kei Miyakawa, Akio Adachi, Masako Nomaguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takaaki KomaDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Bao Quoc LeDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Khanh Quoc TranDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Naoya DoiDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Tomoyuki KondoDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Kei MiyakawaAIDS Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Akio AdachiDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Masako NomaguchiDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process. This article provides an updated overview and perspective on HIV-1 virion assembly, with a particular focus on the role of Gag-RNA interactions.

Indexed as

GagGag multimerizationGag oligomerizationHIV-1membraneRNAvirion assembly

Identifiers

PMID40895469
PMCPMC12392317

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.