Evidence map›Paper›PMID 40895501›Full record

ReviewAmerican journal of lifestyle medicine2025

What Do We Know About Prevention of Frailty in Women?

Julia V Loewenthal, Nicole K Bart, Wren Burton, Shaida Kamali, Elyn Montgomery, Kerry Lee Ivey, Susan M Friedman, Ariela Orkaby

Abstract readReview
In one paragraph

Review in American journal of lifestyle medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia V LoewenthalDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JVL, KLI, AO).
Nicole K BartCardiology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (NKB).
Wren BurtonDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (WB).
Shaida KamaliUniversity of Oklahoma College of Medicine, Boston, MA, USA (SK).
Elyn MontgomeryThe Victor Chang Cardiac Research Institute, Sydney, NSW, Australia (EM).
Kerry Lee IveyDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JVL, KLI, AO).
Susan M FriedmanDivision of Geriatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA (SMF).ORCID https://orcid.org/0000-0003-0876-9888
Ariela OrkabyDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JVL, KLI, AO).ORCID https://orcid.org/0000-0002-4297-6306

Funding

PREVENTABLE Frailty Ancillary StudyR01AG081287 · NIA · BOSTON VA RESEARCH INSTITUTE, INC. · PI ORKABY, ARIELA R · 2024 to 2025
$2.6M
Combined Chiropractic Care and Tai Chi for Chronic Non-Specific Neck PainR34AT011368 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI WAYNE, PETER MICHAEL · 2022 to 2024
$951k
NCCIH NIH HHS R34 AT011368NIA NIH HHS R01 AG081287
6 · The paper itself

Abstract

Frailty is a multidimensional syndrome associated with a state of vulnerability to external stressors. Though women have a longer life expectancy than men, they have a higher risk of frailty. Frailty is prevalent in women, affecting ∼9-15% of community-dwelling older women, and over 50% of nursing home residents. Women have unique risk factors for frailty at distinct life stages such as pregnancy and menopause. Women who have children at a young age and those who experience premature menopause have a higher risk of developing frailty later in life. Frailty is modifiable, and preventive strategies can be implemented using the framework of the six pillars of lifestyle medicine. Moreover, frailty is also a therapeutic target, with the best approach to prevention occurring earlier in life. Implementation of the six-pillar approach to frailty prevention is best achieved by considering specific benefits and barriers to each pillar for women. For example, implementing strength training alongside diet optimization while bolstering social connections. The six pillars are closely interrelated. As such, a holistic approach targeting all six has the greatest potential for success. Future studies are needed to guide therapeutic interventions specific to preventing frailty in women.

Indexed as

agingexercisefrailtymenopausemultimorbiditymultisystem dysregulationnutritionolder adultspregnancypreventionwomen

Identifiers

PMID40895501
PMCPMC12397111

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.