Evidence map›Paper›PMID 40895571›Full record

ArticleFrontiers in immunology2025

Therapeutic vaccination with the Ag85B-Rv2660c-MPT70 fusion protein enhances

Zhiming Hu, Shaohua Guo, Wenlong Chen, Jiangshan Ouyang, Chunxu Huang, Ting Cao, Jun Mou, Xinxia Gu, Jie Liu

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Antigen 85B ofVaccines · 2026
    Review
  2. Article
  3. Article
  4. RecombinantHuman vaccines & immunotherapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiming Hu *Center for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Shaohua Guo *Center for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Wenlong ChenCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Jiangshan OuyangCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Chunxu HuangCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Ting CaoCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Jun MouCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Xinxia GuCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Jie LiuCenter for Infectious Diseases and Vaccine Research, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Latent tuberculosis infection (LTBI), affecting nearly one-quarter of the global population, represents a major barrier to Tuberculosis (TB) eradication and a paradigm of chronic infectious disease. Current chemotherapeutic regimens for TB, although effective, are limited by drug resistance, toxicity, and poor adherence, underscoring the urgent need for alternative strategies. In this study, we investigated ARM-a recombinant fusion protein comprising Ag85B, Rv2660c, and MPT70-as a therapeutic vaccine in a murine model of post-exposure

Indexed as

AcyltransferasesAntigens, BacterialBacterial ProteinsLatent TuberculosisMycobacterium tuberculosisRecombinant Fusion ProteinsTuberculosisTuberculosis VaccinesAnimalsAntibodies, BacterialCD4-Positive T-LymphocytesDisease Models, AnimalFemaleMiceMice, Inbred C57BLVaccinationAcyltransferasesAntibodies, Bacterialantigen 85B, Mycobacterium tuberculosisAntigens, BacterialBacterial ProteinsRecombinant Fusion ProteinsTuberculosis VaccinesAg85Bantibody-dependent phagocytosisMPT70Mycobacterium tuberculosispolyfunctional T cellsRv2660ctherapeutic vaccine

Identifiers

PMID40895571
PMCPMC12391039

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.