ArticleCureus2025
Diagnostic Potential of Salivary Interleukin-8 mRNA and Protein in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: Insights From South India.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Evaluation of salivary biomarkers predicting oral disease activity in apparently healthy individuals.Bioinformation · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Oral squamous cell carcinoma (OSCC) is a common type of head and neck cancer, which is often preceded by oral potentially malignant disorders (OPMDs). Though comprehensive examination forms the backbone of oral cancer screening, the combination of salivary proteomic and transcriptomic markers may identify molecular markers specific to OSCC and assess their ability to predict malignant transformation in OPMD. Hence, this study aimed to determine the diagnostic utility of salivary interleukin-8 (IL-8) mRNA and protein in the differential diagnosis of OSCC, OPMD, and healthy controls. Methodology Unstimulated whole saliva was collected from 90 subjects, 30 in each group (i.e., OSCC, OPMD, and controls). This comparative cross-sectional, multicenter study was conducted after obtaining institutional ethical clearance. The supernatant was treated with RNase inhibitor and separated into the following two fractions: one for RNA extraction and the other for enzyme-linked immunosorbent assay (ELISA). The results were statistically analyzed using SPSS version 21 software (IBM Corp., Armonk, NY, USA), and p-values
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