ArticleBiological psychiatry global open science2025
Brainwide Analysis of Functional Connectivity Patterns in Specific Phobia and Its Treatment.
Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Specific phobia (SP) is a prevalent mental disorder for which exposure-based treatments are the most effective. Little is known about the intrinsic functional connectivity of SP and its modification by treatment. While previous studies were limited to a priori-defined brain regions, we used connectome-wide analyses to capture the full extent of altered functional connectivity. Methods: We used functional magnetic resonance imaging in combination with hypothesis-free, data-driven functional connectivity multivariate pattern analysis (fc-MVPA) to identify differences between 72 individuals with SP and a nonphobic control group (CG) ( Results: fc-MVPA identified the largest differences between the SP group and CG in sensorimotor regions, with lower connectivity to temporal nodes of the default network and anticorrelations with the frontoparietal network in the SP group compared with the CG. Stronger connectivity in the pretreatment compared with the posttreatment condition was evident in visual regions, while anticorrelations with the frontoparietal network were reduced. Post hoc comparisons showed that the connectivity strengths of the SP group after treatment between almost all identified nodes of both contrasts (SP vs. CG and pre vs. post) were comparable to those of the CG at baseline. Conclusions: Given the known functions of the identified networks, it is possible that the changes in connectivity measured after treatment indicate improved action control, enabled by more accurate prediction of the environment and stronger coupling of perceptual and action regions with higher-order control regions.
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Registered trials
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