ArticleCureus2025
Assessing the Impact of All-Trans Retinoic Acid (ATRA)- and Arsenic Trioxide (ATO)-Based Therapy in Pediatric Acute Promyelocytic Leukemia: A Single-Center Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Establishment and validation of a 28-day clinical outcome prediction model for acute promyelocytic leukemia based on an early platelet-coagulation factor combined transfusion strategy.American journal of cancer research · 2026Article
- Combination of cellular retinoic acid-binding protein 2 overexpression and all-trans retinoic acid synergistically inhibits oesophageal squamous cell carcinoma progression.Discover oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by the t(15;17) translocation, leading to the PML-RARA fusion gene. While treatable, APL presents significant challenges, particularly in resource-constrained settings where delays in diagnosis and access to specialized care may impact outcomes. This study aims to describe the clinical presentation, treatment outcomes, and survival data for pediatric APL patients.
methodsThis observational, retrospective, single-center study was conducted at Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, spanning for a period of six years. The study included 20 pediatric patients diagnosed with APL. Laboratory profiles, treatment regimens, and complications were analyzed. Risk stratification was done using modified Sanz criteria, and patients were treated according to the APL0406 and APML4 protocols. Overall survival (OS) and Progression-free survival (PFS) were calculated over a median follow-up period of three years.
resultsMedian OS was 88 months (95% CI= 79.612 to 97.188). The mean haemoglobin levels were 6.51 ± 1.82 mg/dL and patients had high PML-RARA transcript levels (5175.95 ± 3039.37). Common symptoms included mucocutaneous bleeding (19, 95%) and gum bleeding (10, 50%). Induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) lasted a mean of 40.9 days. Febrile neutropenia (16, 80%) and differentiation syndrome (14, 70%) were frequent complications. One patient (1, 5%) died during induction.
conclusionThis study reinforces the effectiveness of ATRA-ATO-based regimens in managing paediatric APL. However, induction-related complications such as febrile neutropenia, transaminitis, and QTc prolongation highlight the need for vigilant monitoring and robust supportive care. Timely diagnosis and early initiation of therapy remain key to improving outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.