ArticleFrontiers in psychiatry2025
Glymphatic system dysfunction in young adults hospitalized for an acute psychotic episode: a preliminary report from a pilot study.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors associated with aggressive behavior in patients with schizophrenia: a systematic review and meta-analysis.BMC psychology · 2026Pooled it
- Increased Activity of the Glymphatic System in First-Episode Psychosis: Relationship With Cortical Thinning.JAACAP open · 2026Article
- Objective Sleep Measures and Cognition in Middle-Aged and Older Adults: A Cross-Sectional and Longitudinal Analysis in the ALBION Study.Medical sciences (Basel, Switzerland) · 2026Article
- Manual Dexterity Rehabilitation in Parkinson's Disease and Paranoid Schizophrenia: A Controlled Study.Life (Basel, Switzerland) · 2026Article
- Cognitive behavioral therapy combined with aripiprazole in the treatment of schizophrenia: effects on cognitive function and psychological state.Frontiers in psychiatry · 2026Article
- Brain Extracellular Space: From an Overlooked Dimension to Catalyst of a Novel Neuroscience Paradigm.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Elevated glutamine but not glutamate is associated with clozapine eligibility in an early psychosis sample.Frontiers in psychiatry · 2026Article
- Elevated prolactin and association with treatment resistance indicators in first-hospitalized schizophrenia spectrum disorders: a real-world cohort study.BMC psychiatry · 2025Article
- Cognitive Remediation as a Tool for Enhancing Treatment Dimensions of Schizophrenic Symptomatology: A Systematic Review of Randomized Controlled Trials.Brain sciences · 2025Review
- Deep learning approaches for EEG-based healthcare applications: a comprehensive review.Frontiers in human neuroscience · 2025Review
- First exposure to second-generation antipsychotics alters gut microbiota and metabolic profiles in patients with glucose-lipid metabolism disorders.Frontiers in psychiatry · 2025Article
- Circuitry correlates of negative urgency and suicidality in schizophrenia spectrum disorders: a LASSO regression study.Frontiers in psychiatry · 2025Article
- Assessing glymphatic-associated fluid dynamics in psychiatric disorders: evidence from neuroimaging - a review.Psychoradiology · 2025Review
- Glymphatic system and psychiatric disorders: need for a new paradigm?Frontiers in psychiatry · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glymphatic system is integral to the elimination of metabolic waste from the central nervous system and has been extensively studied in relation to neurodegenerative and cerebrovascular diseases. Emerging evidence suggests that glymphatic dysfunction may also play a role in psychiatric disorders, including psychosis and schizophrenia. This pilot study investigated glymphatic clearance in young adults hospitalized for an acute psychotic episode using the diffusion tensor imaging (DTI)-derived ALPS (Along Perivascular Spaces) index. Initially, thirteen patients aged 18-30 were recruited; however, only nine completed the DTI protocol due to severe psychiatric symptoms and practical constraints. A non-psychiatric control group comprising twelve individuals was subjected to the same imaging protocol, though precise age matching was not implemented. The study's findings indicated significant reductions in the ALPS index among patients compared to controls, supporting the hypothesis of impaired glymphatic function during acute psychotic episodes. No significant associations were found between glymphatic clearance and sleep quality, disorganized thinking, or general cognitive functioning. Despite the limitations related to the small sample size, these preliminary results highlight the necessity of further research into the glymphatic system's involvement in psychosis. Larger-scale studies are required to elucidate the clinical implications and pathophysiological mechanisms linking glymphatic dysfunction to acute psychosis and early psychotic disorders.
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