ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2025
4-Methylesculetin alleviated aflatoxin B1-induced liver injury and ferritinophagy through AMPK- TOR-Ulk axis in grass carp (
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Compound Abrus cantoniensis Extract Alleviates AFBAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Functional additives in fishmeal-replaced aquafeeds: precision strategies for sustainable aquaculture.Journal of animal science and biotechnology · 2026Review
- Diverse Forms of Autophagy and Their Roles in Liver Disease and Aging: A Comprehensive Review.Proteomes · 2026Review
- Article
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10 authors.
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Abstract
The mycotoxin aflatoxin B1 (AFB1), frequently identified in animal feed and raw materials, induces oxidative stress as a primary toxicological consequence. The coumarin compound 4-methylesculetin (4-ME) possesses notable antioxidant properties, leading to its application in medical contexts. Given that the liver is the principal organ targeted by AFB1, this study investigated the potential mechanism through which 4-ME mitigated hepatic injury induced by AFB1 in grass carp. The grass carp (initial body weight of 11.40 ± 0.01 g) were randomly divided into 4 treatment groups (3 replicates/treatment and 60 fish/replicate), which were control group (Control), 60 μg/kg AFB1 group (AFB1), 10 mg/kg 4-ME group (4-ME) and 60 μg/kg AFB1 + 10 mg/kg 4-ME group (AFB1 + 4-ME). The present study found that AFB1 caused liver injury, dietary 4-ME supplementation enhanced the antioxidant capacity through the Nrf2 pathway, decreased the levels of AFB1-DNA adducts (
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