Evidence map›Paper›PMID 40897177›Full record

ArticleCell reports. Medicine2025

Zeaxanthin augments CD8

Freya Q Zhang, Jiacheng Li, Rukang Zhang, Jiayi Tu, Zhicheng Xie, Takemasa Tsuji, Hardik Shah, Matthew O Ross, Ruitu Lyu, Junko Matsuzaki and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Freya Q ZhangDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Jiacheng LiDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Rukang ZhangDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Jiayi TuDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Zhicheng XieDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Takemasa TsujiDepartment of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA.
Hardik ShahDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Matthew O RossDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Ruitu LyuDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Junko MatsuzakiDepartment of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA.
Anna TaborDepartment of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA.
Kelly XueDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Fatima ChoudhryHealth Science, DePaul University, Chicago, IL 60614, USA.
Chunzhao YinDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Hamed R YoushanloueiDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Syed ShahDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Michael W DrazerDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Yu-Ying HeDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
B Marc BissonnetteDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Yuancheng LiDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Hui MaoDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jun HuangPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA.
Lei DongUniversity of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rui SuDepartment of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Kunle OdunsiDepartment of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA.
Jing ChenDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: jingchen@uchicago.edu.
Hao FanDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: haofan@uchicago.edu.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Tyrosine Kinase Signaling in Cancer Cell MetabolismR01CA140515 · NCI · UNIVERSITY OF CHICAGO · PI Jing Chen · 2010 to 2026
$5.4M
Epitranscriptomic mechanism of environmental stress response and tumorigenesisR35ES031693 · NIEHS · UNIVERSITY OF CHICAGO · PI Yu-Ying He · 2023 to 2026
$4.2M
Signaling and Targeting of 6-Phosphogluconate Dehydrogenase in Human CancersR01CA174786 · NCI · UNIVERSITY OF CHICAGO · PI CHEN, JING · 2014 to 2024
$3.7M
Dietary trans-vaccenic acid enhances anti-tumor immunityR01CA276568 · NCI · UNIVERSITY OF CHICAGO · PI Jing Chen · 2023 to 2026
$1.5M
NCI NIH HHS R01 CA140515NCI NIH HHS R01 CA174786NCI NIH HHS R01 CA276568NCI NIH HHS T32 CA009594NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R35 ES031693
6 · The paper itself

Abstract

The detailed mechanisms underlying the regulatory significance of dietary components in modulating anti-tumor immunity remain largely unknown. Here, we apply a co-culture-based screening approach using a blood nutrient compound library and identify zeaxanthin (ZEA), a dietary carotenoid pigment found in many fruits and vegetables and known for its role in eye health, as an immunomodulator that enhances the cytotoxicity of CD8

Indexed as

CD8-Positive T-LymphocytesImmunotherapyZeaxanthinsAnimalsCell Line, TumorFemaleHumansMiceMice, Inbred C57BLReceptors, Antigen, T-CellReceptors, Antigen, T-CellZeaxanthins

Identifiers

PMID40897177
PMCPMC12490228

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.