ArticleJournal of advanced research2026
FungiSNC: An integrated database for fungi small non-coding RNAs based on high-throughput sequencing.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- tRNA‑derived RNAs in hepatic diseases: From biological functions to clinical translation (Review).International journal of molecular medicine · 2026Review
- TheBiology · 2026Article
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Authors and funding
10 authors.
Funding
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Abstract
introductionSmall non-coding RNAs (sncRNAs) have been proven to play crucial roles in various biological processes such as development, stress responses, virulence, and pathogenicity. However, to the best of our knowledge, none of the currently available databases can store, manage, and analyze the vast amounts of sncRNA sequencing data. A comprehensive web-based platform for the integration and analysis of sncRNAs in fungi and their potential functions is still lacking.
objectivesTo provide an integrated database for fungi sncRNAs. It represents the first comprehensive platform encompassing diverse categories of sncRNAs.
methodsWe implemented a standardized analytical workflow encompassing (i) data preprocessing of both public repositories and in-house sRNA-seq datasets, (ii) systematic sncRNA detection and classification, and (iii) functional annotation analysis, with all results integrated into a relational database featuring embedded analytical tools for user-friendly exploration.
resultsWe herein present FungiSNC (https://rnainformatics.org.cn/FungiSNC), an integrated database for fungal sncRNAs. It represents the first comprehensive platform encompassing diverse categories of sncRNAs, including siRNAs (small-interfering RNAs), predicted milRNAs (microRNA-like RNAs) and phasiRNAs (phased, secondary, small-interfering RNAs), rRNAs (ribosomal RNAs), tRNAs (transfer RNAs), snRNAs (small nuclear RNAs), snoRNAs (small nucleolar RNAs), piRNAs (piwi-interacting RNAs) and tRFs (tRNA-derived small RNA fragments), aggregating 989 next generation sequencing (NGS) samples from 29 fungal species.
conclusionsFungiSNC (Fungal Small Non-Coding RNA Database), is the first comprehensive platform dedicated to the curation, annotation, and functional analysis of fungal sncRNA sequencing data. By bridging fragmented data resources with advanced computational tools, FungiSNC aims to facilitate mechanistic exploration of sncRNA-mediated regulatory networks in fungal biology, with important implications for antifungal therapy and agricultural biocontrol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.