Evidence map›Paper›PMID 40897446›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

The role of α

Julia E Spafford, Jacqueline K Limberg, Ronée E Harvey, Chad C Wiggins, Nathaniel J Iannarelli, Jonathon W Senefeld, Wayne T Nicholson, Timothy B Curry, Michael J Joyner, J Kevin Shoemaker and 2 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julia E SpaffordDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.ORCID 0009-0004-2110-5079
Jacqueline K LimbergDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-9982-5851
Ronée E HarveyDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-8861-5477
Chad C WigginsDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-6458-0142
Nathaniel J IannarelliDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0002-6188-4829
Jonathon W SenefeldDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-8116-3538
Wayne T NicholsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Timothy B CurryDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7135-7643
J Kevin ShoemakerDepartment of Physiology and Pharmacology, School of Kinesiology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-6794-5979
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-9647-7660
Stephen A KlassenDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0002-4560-8728

Funding

DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
Hot Flashes and Neurovascular Function in WomenK01HL148144 · NHLBI · MAYO CLINIC ROCHESTER · PI BAKER, SARAH ELIZABETH · 2021 to 2025
$867k
Skeletal muscle performance and cellular adaptations to high hemoglobin-oxygen affinityF32HL154320 · NHLBI · MAYO CLINIC ROCHESTER · PI SENEFELD, JONATHON · 2020 to 2021
$117k
American Heart Association (AHA) AHA15SDG2508009Brock UniversityCanada Research Chairs (Chaires de recherche du Canada)Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 00320Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 05293Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 217916Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) Undergraduate Student Research AwardHHS | National Institutes of Health (NIH) K01-HL-148144HHS | National Institutes of Health (NIH) R-35-HL-139854HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32-HL-154320HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32-DK-007352NHLBI NIH HHS F32 HL154320NHLBI NIH HHS K01 HL148144NHLBI NIH HHS R35 HL139854NIDDK NIH HHS T32 DK007352Ontario Government | Ministère de l'Éducation, Gouvernement de l'Ontario (EDU) Ontario Graduate Scholarship ProgramQueen Elizabeth Scholars (QES)
6 · The paper itself

Abstract

This study tested the hypothesis that neural and vascular α

Indexed as

Adrenergic alpha-2 Receptor AgonistsBaroreflexBlood PressureDexmedetomidineMuscle, SkeletalReceptors, Adrenergic, alpha-2Sympathetic Nervous SystemAction PotentialsAdultFemaleHumansMaleYoung AdultAdrenergic alpha-2 Receptor AgonistsDexmedetomidineReceptors, Adrenergic, alpha-2action potentialdexmedetomidinemicroneurographymuscle sympathetic nerve activityα2-adrenergic

Identifiers

PMID40897446
PMCPMC12477650

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.