Evidence map›Paper›PMID 40897451›Full record

ArticleAmerican journal of physiology. Cell physiology2025

The role of carnitine palmitoyl transferase 2 in the progression of salt-sensitive hypertension.

Lashodya V Dissanayake, Brody A Smith, Adrian Zietara, Vladislav Levchenko, Melissa Lowe, Olha Kravtsova, Abigail Shapiro, Gunjan Upadhyay, Ganesh V Halade, Aron M Geurts and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lashodya V DissanayakeDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-2329-0931
Brody A SmithDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Adrian ZietaraDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-7465-060X
Vladislav LevchenkoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Melissa LoweDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Olha KravtsovaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-4280-9399
Abigail ShapiroDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Gunjan UpadhyayDepartment of Internal Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0009-0002-2669-1607
Ganesh V HaladeDepartment of Internal Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-5351-9354
Aron M GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-4347-2505
Oleg PalyginDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States.ORCID 0000-0002-3680-5527
Alexander StaruschenkoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-5190-8356

Funding

Sexual dimorphisms and role of the cGAS-STING pathway in diabetic nephropathyR01DK135644 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI Alexander Staruschenko · 2023 to 2026
$2.0M
Renal diabetic complications mediated by the PAR1 signaling in podocytesR01DK129227 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI PALYGIN, OLEG, STARUSCHENKO, ALEXANDER · 2022 to 2025
$1.3M
American Heart Association (AHA) Postdoctoral FellowshipBLRD VA I01 BX004024Dialysis Clinics (DCI) Paul Teschan Research FundNIDDK NIH HHS R01 DK129227NIDDK NIH HHS R01 DK135644University of South Florida (USF) Hypertension and Kidney Research Center Early-Stage Investigator Pilot Award
6 · The paper itself

Abstract

Carnitine palmitoyl transferase 2 (CPT2) is a key enzyme in mitochondrial fatty acid oxidation (FAO), a process critical for renal energy homeostasis. Disruption of FAO and accumulation of plasma acylcarnitines (fatty acids conjugated to carnitine) have been implicated in renal and vascular diseases. Although the kidney relies heavily on FAO, the specific renal consequences of CPT2 deficiency remain poorly understood. Clinical data suggest that CPT2 expression may be associated with increased lifespan in patients on antihypertensive therapy, yet a direct link between CPT2 and hypertension has not been established. Our previous work in salt-sensitive (SS) hypertension showed that a high-salt (HS) diet increases FAO while reducing renal acylcarnitine levels. To investigate how CPT2 deficiency affects renal function and metabolic regulation under dietary stress, we generated a novel CPT2-deficient rat model on the Dahl SS background. Homozygous knockouts were embryonically lethal; thus, heterozygous (

Indexed as

Carnitine O-PalmitoyltransferaseHypertensionSodium Chloride, DietaryAnimalsBlood PressureCarnitineDisease Models, AnimalDisease ProgressionFatty AcidsKidneyMaleMitochondriaRatsRats, Inbred DahlacylcarnitineCarnitineCarnitine O-PalmitoyltransferaseFatty AcidsSodium Chloride, Dietaryacylcarnitinescarnitine palmitoyl transferase 1 and 2fatty acid oxidationhigh-salt dietketogenic diet

Identifiers

PMID40897451
PMCPMC12462776

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.