Evidence map›Paper›PMID 40897798›Full record

ArticleOncogene2025

Integrated control of cancer stemness by σ

Gianluca Civenni, Giada Sandrini, Jessica Merulla, Carola Musumeci, Elisa Federici, Arianna Vallegra, Aleksandra Kokanovic, Simone Mosole, Dheeraj Shinde, Elisa Sorrenti and 15 more

Abstract read
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Gianluca CivenniInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0003-1921-161X
Giada SandriniInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0002-7294-3863
Jessica MerullaInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Carola MusumeciInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0009-0002-7611-0743
Elisa FedericiInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0009-0005-8531-1864
Arianna VallegraMario Negri Institute for Pharmacological Research, Milano, Italy.ORCID 0000-0002-5623-2412
Aleksandra KokanovicInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Simone MosoleInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0009-0008-4400-3488
Dheeraj ShindeInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0002-5113-3167
Elisa SorrentiInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0002-3905-647X
Alyssa J J PaganoniInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0001-9393-9356
Martina MarchettiInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Riccardo ValzelliInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0009-0007-2037-2513
Domenico AlbinoInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0001-6249-4163
Matteo PecoraroInstitute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0009-0002-8105-9671
Andrea RinaldiInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0003-3234-0563
Marco BolisInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0003-4377-5079
Roger GeigerInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0002-8016-1669
Tobias WingeInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Catharina HoltschulteInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Erik LauriniMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, Trieste, Italy.
Sabrina PriclMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, Trieste, Italy.ORCID 0000-0001-8380-4474
Giuseppina M CarboneInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.ORCID 0000-0003-4652-585X
Bernhard WünschInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Münster, Germany.ORCID 0000-0002-9030-8417
Carlo V CatapanoInstitute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland. carlo.catapano@ior.usi.ch.ORCID 0000-0002-7079-557X

Funding

Krebsliga Schweiz (Ligue Suisse Contre le Cancer) KLS-4569-08-2018Krebsliga Schweiz (Ligue Suisse Contre le Cancer) KLS-4899-08-2019Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) SNSF-310030_189081Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) SNSF-310030L_170182Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) SNSF-IZLSZ3_170898
6 · The paper itself

Abstract

Cancer stem cells (CSCs) are pervasively present in human cancers and have a fundamental role in treatment failure and disease recurrence. Identifying critical elements that sustain the CSC phenotype may lead to novel strategies for cancer treatment. Here, we provide evidence of an essential link between the σ

Indexed as

Neoplastic Stem CellsProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantReceptors, sigmaAnimalsbeta CateninCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleMiceMitochondriaSigma-1 ReceptorSignal Transductionbeta CateninReceptors, sigmaSigma-1 Receptor

Identifiers

PMID40897798
PMCPMC12518131

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.