Evidence map›Paper›PMID 40897863›Full record

ReviewMolecular psychiatry2025

Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia.

Lalit K Ahirwar, Spiros L Blackburn, Devin W McBride, Peeyush Kumar T

Abstract readReview
In one paragraph

Review in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Alcohol Metabolism into Acetaldehyde in Developing Cerebral Arteries.International journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lalit K AhirwarThe Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, 6431 Fannin St. MSB 7.147, Houston, TX, 77030, USA.
Spiros L BlackburnThe Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, 6431 Fannin St. MSB 7.147, Houston, TX, 77030, USA.
Devin W McBrideThe Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, 6431 Fannin St. MSB 7.147, Houston, TX, 77030, USA.
Peeyush Kumar TThe Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, 6431 Fannin St. MSB 7.147, Houston, TX, 77030, USA. peeyush.k.thankamanipandit@uth.tmc.edu.ORCID http://orcid.org/0000-0002-5681-6602

Funding

Endothelial Cell Epigenetics and Blood-Brain Barrier.R01NS121339 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI THANKAMANI PANDIT, PEEYUSH KUMAR · 2021 to 2025
$2.3M
Neuroregeneration after stroke using Vascular GuidanceR21NS135176 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI THANKAMANI PANDIT, PEEYUSH KUMAR · 2024 to 2025
$416k
NINDS NIH HHS R01 NS121339NINDS NIH HHS R21 NS135176
6 · The paper itself

Abstract

During cortical development, newly born neurons migrate radially or tangentially from their origin to expand the cortex. Simultaneously, neuron-derived factors support angiogenesis, and an elaborate network of blood cerebral vessels develops in the cortex. Traditionally, blood cerebral vessels were considered to support the growing cortex or migrating neurons by providing nutrients and oxygen. However, recent studies have shed light on Endothelial cells' influence on cortical development; they guide neuronal migration by providing molecular cues and structural support. Here, we review the current understanding of how CNS cerebral vessels support neurogenesis, neuronal migration, and the formation of the six-layer cortical structure during development. Additionally, we explore current knowledge regarding the vascular role in neurodevelopmental disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, and schizophrenia.

Indexed as

Cerebral CortexNeurodevelopmental DisordersAnimalsAttention Deficit Disorder with HyperactivityAutistic DisorderCell MovementEndothelial CellsHumansNeurogenesisNeuronsSchizophrenia

Identifiers

PMID40897863
PMCPMC12602333

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.