Evidence map›Paper›PMID 40897938›Full record

ArticleJournal of neurology2025

Progressive retinal and microvascular neurodegeneration in neuromyelitis optica spectrum disorders: a longitudinal SS-OCT/OCTA study.

Lingyao Kong, Xiaofeng Tan, Hang Wang, Le Cao, Ziyan Shi, Nana Zhang, William Robert Kwapong, Rui Wang, Dongren Sun, Yangyang Zhang and 5 more

Abstract read
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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lingyao Kong *Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Xiaofeng Tan *State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Hang Wang *Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Le CaoDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Ziyan ShiDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Nana ZhangDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
William Robert KwapongNeurology Department, Xuanwu Hospital, Beijing Capital University, Changchun Street, Beijing, China.
Rui WangDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Dongren SunDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Yangyang ZhangDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Ying ZhangDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Zichao MouDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Xiaofei WangDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China.
Bo WuDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China. dr.bowu@hotmail.com.
Hongyu ZhouDepartment of Neurology, West China Hospital, Sichuan University, Guo Xuexiang 37, Chengdu, 610041, China. zhouhy@scu.edu.cn.ORCID http://orcid.org/0000-0002-7637-1305

Funding

National Natural Science Foundation of China 82201494National Natural Science Foundation of China 82471376
6 · The paper itself

Abstract

backgroundEmerging evidence suggests that subclinical visual pathway impairment might occur in neuromyelitis optica spectrum disorder (NMOSD) independently of optic neuritis (ON). This prospective longitudinal cohort study aims to characterize dynamic retinal neurodegeneration and microvascular alterations in NMOSD.

methodsThe quantitative parameters from swept-source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA) included the macular retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, superficial vascular complex (SVC) density, and deep vascular complex (DVC) density. Multivariable linear mixed-effects models adjusted for age, sex, treatment, follow-up time, and ON history were used to analyze correlations between SS-OCT/OCTA parameters and clinical features.

resultsCross-sectional analysis demonstrated significant reductions in the RNFL thickness (33.91 ± 8.90 vs. 38.88 ± 4.00 μm, p < 0.001), GCIPL thickness (54.89 ± 11.06 vs. 64.42 ± 5.28 μm, p < 0.001), and SVC density (38.17 ± 10.21% vs. 45.96 ± 3.83%, p < 0.001) in NMOSD patients versus healthy controls, along with reduced RNFL thickness (33.91 ± 8.90 μm vs. 36.22 ± 8.62 μm; p = 0.011) and SVC density (38.17 ± 10.21% vs. 40.66 ± 6.62%; p = 0.016) relative to patients with multiple sclerosis. Longitudinal analysis demonstrated a progressive decline in GCIPL thickness (- 0.18 µm/year, IQR: - 1.69 to 1.72 µm/year, p = 0.047), SVC density (- 1.11%/year, IQR:-2.90% to 0.87%/year, p = 0.003), and DVC density (- 1.88%/year, IQR: - 3.52% to 0.50%/year, p = 0.004) from baseline among clinically stable NMOSD patients. The annual degradation rate of GCIPL thickness showed significant inverse correlations with baseline logMAR visual acuity (p < 0.001), ON frequency (p < 0.001) and baseline EDSS scores (p = 0.039). DISCUSSION: Our findings indicate that progressive retinal neurodegeneration and microvascular loss persist independently of clinical relapse, positioning SS-OCT/OCTA metrics as sensitive biomarkers for subclinical progression and supporting their integration into the framework of disease monitoring and treatment response assessment.

Indexed as

MicrovesselsNeuromyelitis OpticaRetinaRetinal DegenerationRetinal VesselsAdultCross-Sectional StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesTomography, Optical CoherenceGCIPLNeurodegenerationNeuromyelitis optica spectrum disordersRNFLSwept-source optical coherence tomography

Identifiers

PMID40897938

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.