Evidence map›Paper›PMID 40898021›Full record

Observational studyBMC anesthesiology2025

Comparison of the incidence of reperfusion syndrome and outcomes of liver transplantation among pediatric recipients of partial vs. whole graft: report of six-year retrospective study.

Fatemeh Khalili, Mohammad Bagher Khosravi, Mohammad Ali Sahmeddini, Mohammad Hossein Eghbal, Fatemeh Kanaani Nejad, Mahsa Banifatemi, Naeimehossadat Asmarian

Abstract readComparative StudyObservational Study
In one paragraph

Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fatemeh KhaliliAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Bagher KhosraviAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Ali SahmeddiniAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. sahmeddini@sums.ac.ir.ORCID http://orcid.org/0000-0003-1510-0103
Mohammad Hossein EghbalAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatemeh Kanaani NejadAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahsa BanifatemiAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Naeimehossadat AsmarianAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvancements in graft selection, surgical and anesthetic techniques have improved the outcomes of pediatric liver transplantation over the last few decades. In this study, we evaluate preoperative factors, the incidence of post-reperfusion syndrome, rejection, and survival among 523 pediatric patients who received whole vs. partial liver transplantation.

methodsIn a six-year retrospective observational study on 523 pediatric liver transplantation recipients (age < 18 years old) in Abu-Ali Sina Organ Transplantation Hospital, we collected recipients' demographic data, warm and cold ischemic time, post reperfusion syndrome, and postoperative outcomes, including mechanical ventilation time, ICU length of stay, acute renal failure, acute cellular rejection, re-transplantation, and patients' survival. We compared these preoperative, operative, and postoperative outcomes among whole and partial graft recipients using SPSS software for Windows.

results259 cases received partial and 264 cases received whole organ transplantation. We compared the donor factors, preoperative, intraoperative recipient factors, and postoperative outcomes between the two groups. The donors' age and percentage of macrovesicular steatotic changes of the partial donor graft were significantly higher than the whole donor graft, respectively (33.5 vs. 6,p < 0.001) (31% vs. 17%,p < 0.001). The recipients of partial graft had younger age (3.5 (1.5-8) vs. 9 (5-14) years, P < 0.001) than recipients of whole organ graft. Although partial organ recipients had shorter cold ischemic time (25 (15-30) vs. 480 (390-570) minutes, P < 0.001), they significantly developed post-reperfusion syndrome more than whole organ recipients (14% vs. 7.5%, P = 0.01). The outcome of partial organ recipients also seemed to be poorer compared with whole organ recipients; they had longer ICU stays (18 (11-29) vs. 14 (9-20) days, P = 0.004) and lower survival (61.4% vs. 81.8%, P < 0.001).

conclusionAlthough partial organ transplantation provides more chances for pediatric liver transplant candidates to survive, we observed that physicians have faced many challenges, and children had more complications and lower survival after partial organ transplantation.

Indexed as

Liver TransplantationPostoperative ComplicationsReperfusion InjuryAdolescentChildChild, PreschoolFemaleGraft RejectionHumansIncidenceInfantLength of StayMaleRetrospective StudiesTreatment OutcomeLiver graftingLiving donorPediatricsReperfusion injuriesSurvivalTransplant recipients

Identifiers

PMID40898021
PMCPMC12403854

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.