ArticleBMC pregnancy and childbirth2025
The development and validation of postpartum hemorrhage prediction models for pregnancies with placenta previa totalis based on coagulation function indexes: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- A Systematic Evaluation of Cohort Selection Criteria and Their Impact on Machine Learning Model Performance and Demographic Disparities in COVID-19 Outcomes: Cohort Study.JMIR formative research · 2026Article
- The impact of the integrated labor-delivery-recovery-postpartum unit on maternal-neonatal outcomes and psychological experiences among low-risk parturients: a prospective cohort study from a high-volume tertiary center in china.Frontiers in medicine · 2026Article
- Artificial intelligence for postpartum hemorrhage: a systematic review.Frontiers in global women's health · 2026Review
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10 authors.
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Abstract
backgroundThe objective of this study is to establish and validate models that can accurately predict postpartum hemorrhage (PPH) in women with placenta previa totalis prior to undertaking cesarean delivery.
methodsA retrospective cohort study was conducted on 306 pregnancies with placenta previa totalis delivered between January 2011 and June 2022. The pregnancies were classified into two groups, PPH group and non-PPH group, based on bleeding volume and red blood cell transfusion. Clinical features and pre-operative coagulation function indexes were recorded. The entire cohort was randomly divided into a development cohort (n = 214) and a test cohort (n = 92). Least absolute shrinkage and selection operator (LASSO) was implemented to select significant predictors, followed by step-wise logistic regression analysis to build the prediction model. Additionally, machine learning-based models were compared with the proposed model.
resultsAmong 306 participants, 115 (53.74%) and 50 (54.35%) cases of PPH were observed in the development and test cohorts, respectively. The LASSO-Logistic regression model incorporated preoperative serum fibrinogen level, history of prior cesarean delivery and history of antepartum bleeding as predictors. The model yielded an area under the receiver operating characteristic (ROC) curve of 0.721 (95% CI 0.652-0.790) in the development cohort and 0.706 (95% CI 0.600-0.813) in the test cohort. Additionally, the model demonstrated a specificity of 70.7% (95% CI 61.7-79.7%) and a positive predictive value of 72.1% (95% CI 63.5-80.7%) for distinguishing between PPH and non-PPH cases. The LASSO-Logistic regression model outperformed the machine learning based model in the test cohort, confirming its efficiency in predicting PPH in patients with placenta previa totalis.
conclusionsThis study successfully developed and validated a LASSO-Logistic regression model incorporating coagulation indicators to predict PPH in patients with placenta previa totalis. Further large-scale prospective studies are warranted to externally validate the three-variate-based model and assess its practical application in real-time practice.
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