Evidence map›Paper›PMID 40898079›Full record

ArticleBMC pregnancy and childbirth2025

Comorbidities in pregnant South African women living with HIV and associations with adverse birth outcomes: a prospective cohort study.

Amohelang J Lehloa, Emma Kalk, Mary-Ann Davies, Dorothy Nyemba, Ushma Mehta, Thokozile Malaba, Gregory Petro, Andrew Boulle, Landon Myer, Hlengiwe P Madlala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amohelang J LehloaCentre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa. lhlamo001@myuct.ac.za.
Emma KalkCentre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa.
Mary-Ann DaviesCentre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa.
Dorothy NyembaDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory , Cape Town , Western Cape , 7925, South Africa.
Ushma MehtaCentre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa.
Thokozile MalabaDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory , Cape Town , Western Cape , 7925, South Africa.
Gregory PetroDepartment of Obstetrics and Gynaecology, University of Cape Town and New Somerset Hospital, Cape Town, Western Cape, South Africa.
Andrew BoulleCentre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa.
Landon MyerDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory , Cape Town , Western Cape , 7925, South Africa.
Hlengiwe P MadlalaDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory , Cape Town , Western Cape , 7925, South Africa.

Funding

NICHD NIH HHS R01 HD080465
6 · The paper itself

Abstract

backgroundDespite improved health and survival due to lifelong antiretroviral therapy (ART), women living with HIV (WHIV) still face lower life expectancy, partly due to increased non-communicable disease (NCD) risk. Both HIV and NCDs are linked to adverse birth outcomes, yet data on their combined impact are limited. We investigated NCD burden by HIV status and compared adverse birth outcomes in pregnant WHIV only versus HIV-NCD comorbidity in Cape Town, South Africa.

methodsPregnant WHIV (n = 479) and without HIV (n = 510) were enrolled and prospectively followed for pregnancy outcome. Weight and height measurements were serially collected by a study nurse, and diagnoses of hypertension and diabetes mellitus (DM) were made by healthcare providers as part of routine care (ANC). Birth outcomes were abstracted from health records. Proportions described adverse outcomes between groups. Logistic regression was used to estimate associations between HIV and HIV-NCD with small for gestational age (SGA), large for gestational age (LGA), preterm delivery (PTD), low birthweight (LBW), and high birthweight (HBW) (reference: group with neither HIV nor NCDs).

resultsAmong 989 pregnant women, 48% (n = 479) with HIV (median age 29 years, IQR 25-34), the prevalence of obesity (BMI ≥ 30 kg/m

conclusionThere was no difference in the prevalence of NCD in pregnant women by HIV status. Increased risk of adverse birth outcomes was demonstrated with concurrent NCD regardless of HIV status. Integration of NCD screening and management within ANC could minimise excess adverse outcomes in high HIV burden settings.

Indexed as

HIV InfectionsNoncommunicable DiseasesPregnancy Complications, InfectiousPregnancy OutcomeAdultComorbidityDiabetes MellitusFemaleHumansHypertensionInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgePregnancyPremature BirthProspective StudiesAdverse birth outcomesDiabetesHIVHypertensionObesityPregnancy

Identifiers

PMID40898079
PMCPMC12406354

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.