ArticleNutrition & metabolism2025
The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study.
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Research on dietary sodium with invalid methods does not advance scientific understanding.Nutrition & metabolism · 2026Article
- Frequency of adding salt to foods, metabolic signature, and the risk of extracoronary atherosclerotic vascular disease progression.Frontiers in nutrition · 2026Article
- High Salt Intake and Atherosclerosis Progression-Not Only via Blood Pressure: A Narrative Review.Nutrients · 2025Review
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10 authors.
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Abstract
backgroundUntargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort.
methodsThis cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50-64 years, n = 8,957). Sodium intake was estimated using the Kawasaki formula (est24hNa) from urine samples. Plasma metabolites were measured using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) (Metabolon Inc
resultsEst24hNa was significantly associated with the lipid and energy CC. Lower est24hNa was linked to higher concentrations of free fatty acids and citric acid cycle intermediates, suggesting enhanced beta-oxidation. Bonferroni-adjusted analyses revealed 231 metabolites significantly associated with est24hNa, with 2 S,3R-dihydroxybutyrate (β = -0.13, p = 2.28 × 10
conclusionsLower salt intake was associated with a metabolic profile indicative of increased beta-oxidation, while higher salt intake was linked to lipid species previously implicated in atherosclerosis. These findings highlight potential metabolic pathways through which salt intake may influence cardiovascular health and merit further evaluation in longitudinal studies.
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