ArticlePerioperative medicine (London, England)2025
Effective doses of alfentanil combined with propofol for gastroscopy in patients of different ages under Narcotrend monitoring: a prospective dose-finding study utilizing the up-and-down sequential allocation method.
Article in Perioperative medicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPainless gastroscopy is preferred by both patients and physicians, as it minimizes discomfort during the procedure. Alfentanil, a short-acting opioid analgesic, possesses pharmacological properties that make it suitable for inducing analgesia during gastroscopy. However, research on the optimal dosage of alfentanil when used in combination with propofol for gastroscopy is limited. Therefore, this study aimed to investigate the 50% and 95% effective doses (ED50 and ED95, respectively) of alfentanil in combination with propofol for gastroscopy, using Narcotrend monitoring.
methodsElective gastroscopy was performed in 51 patients aged 18-80 years, with a body mass index of 18-28 kg/m
resultsUnder the sedation conditions induced using alfentanil and propofol and detected using Narcotrend, the ED50 (95% CI) were 5.39 µg/kg (4.76-6.47) in the youth group and 5.69 µg/kg (4.67-6.31) in the elderly group, respectively.
conclusionsThe ED50 of alfentanil combined with propofol for gastroscopy under Narcotrend monitoring were 5.39 µg/kg in the youth group and 5.69 µg/kg in the elderly group, respectively.
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