Evidence map›Paper›PMID 40898383›Full record

SynthesisPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2025

Control of Allergic Rhinitis and Asthma Test for Children (CARATkids): A systematic review and meta-analysis of its measurement properties.

Hadla Sami El Didi, Ana Margarida Pereira, Cristina Jácome, Rita Amaral, Gustavo F Wandalsen, Joyce Emons, Stefania La Grutta, Giovanna Cilluffo, Sehra Birgül Batmaz, Daniela Linhares and 4 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Control of Allergic Rhinitis and Asthma Test for Children (CARATkids): A systematic review and meta-analysis of its measurement properties.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hadla Sami El DidiDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.
Ana Margarida PereiraDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-5468-0932
Cristina JácomeDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-1151-8791
Rita AmaralDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-0233-830X
Gustavo F WandalsenEscola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2173-4380
Joyce EmonsDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Stefania La GruttaInstitute of Translational Pharmacology, National Research Council, Palermo, Italy.
Giovanna CilluffoDepartment of Earth and Marine Sciences, DiSTeM, University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0003-4305-3981
Sehra Birgül BatmazDepartment of Pediatric Allergy and Clinical Immunology, Tokat State Hospital, Tokat, Turkey.ORCID https://orcid.org/0000-0003-1913-5346
Daniela LinharesDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.
Dirceu SoleEscola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3579-0861
Bernardo Sousa-PintoDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-1277-3401
João Almeida FonsecaDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-0887-8796
Rafael José VieiraDepartment of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, RISE-Health, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0003-1834-3055

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Control of Allergic Rhinitis and Asthma Test for Children (CARATkids) is the first patient-reported outcome measure (PROM) designed to assess both allergic rhinitis and asthma simultaneously in children aged 6 to 12 years. CARATkids has been validated in several languages and countries, highlighting the need for a review of its psychometric properties. This study aims to evaluate the measurement properties of CARATkids. This systematic review follows PRISMA and COSMIN guidelines. A systematic search was performed across three databases (Ovid/MEDLINE, Web of Science, and Scopus in October 2023, updated in June 2025). We included studies focused on the development, cultural adaptation, or validation of CARATkids, as well as studies comparing CARATkids with other PROMs. We evaluated the quality of CARATkids development, the methodological quality of primary studies, the overall rating, and the certainty of evidence for each CARATkids measurement property and performed a meta-analysis of its measurement properties. Our search retrieved 193 results. We included nine studies. CARATkids displayed sufficient content validity. Regarding internal consistency, we found a meta-analytical Cronbach alpha of 0.81 (95% CI = 0.79; 0.83). CARATkids displayed sufficient reliability (meta-analytical intraclass correlation coefficient 0.86 [95% CI = 0.61; 0.96]). The minimal clinically important difference was 2.76. Construct validity had sufficient evidence for most correlations, with absolute meta-analytical Spearman coefficients from 0.37 to 0.71. Responsiveness showed strong correlations between CARATkids and most outcome measurement instruments. These findings support CARATkids as a suitable tool for assessing asthma and allergic rhinitis in children aged 6 to 12 years who present both conditions simultaneously.

Indexed as

AsthmaPatient Reported Outcome MeasuresRhinitis, AllergicChildHumansPsychometricsReproducibility of ResultsAllergic rhinitisasthmaCARATkidsCOSMINpatient‐reported outcomespsychometrics

Identifiers

PMID40898383
PMCPMC12405605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.