Evidence map›Paper›PMID 40898416›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers.

Timo Kaleck, Rafael Campos-Martin, Amanda Cano, Maria Victoria Fernández, Pamela Martino-Adami, Luca Kleineidam, Victor M Andrade Fuentes, Kumar P Tripathi, Kayenat Parveen, Raquel Puerta and 25 more

Abstract readLetter
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Delineating blood DNA methylation biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Timo KaleckDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Rafael Campos-MartinDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Amanda CanoAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Maria Victoria FernándezAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Pamela Martino-AdamiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Luca KleineidamDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.
Victor M Andrade FuentesDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Kumar P TripathiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Kayenat ParveenDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Raquel PuertaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Itziar de RojasAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Kishore A RavichandranGerman Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany.
Oliver PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Julian Hellmann-RegenGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Josef PrillerGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Maria GemenetziGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Anja SchneiderDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.
Jens WiltfangGerman Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Katharina BuergerGerman Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
Robert PerneczkyGerman Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
Stefan TeipelGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Christoph LaskeGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Frederic BrosseronGerman Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany.
Marta MarquiéAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Daniel LA van den HoveDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands.
Mercè BoadaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Michael T HenekaDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.
Michael WagnerDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.
Natalie MarchantDivision of Psychiatry, University College London, London, UK.
Jean-Charles LambertUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen N, Denmark.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany.
Agustín RuizAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0003-4991-763X

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Agency for Innovation and Entrepreneurship PR067/21Deutsche Forschungsgemeinschaft RA1971/7-1Flander Innovation and Entrepreneurship (VLAIO) PR067/21German Federal Ministry of Education and Research (BMBF) 01ED1614BGerman Federal Ministry of Education and Research (BMBF) 01ED2007AGerman Federal Ministry of Education and Research (BMBF) 01EK2102AInnovative Medicines Initiative 115975Instituto de Salud Carlos III N°AC19/00097Medical Research Council MR/T046171/1National Institute of AgingNIA NIH HHS P30 AG066546NIH HHS P30AG066546Spanish Ministry of Science and Innovation, Proyectos de Generación de Conocimiento PID2019-106625RB-I00Spanish Ministry of Science and Innovation, Proyectos de Generación de Conocimiento PID2021-122473OA-I00Spanish Ministry of Science and Innovation, Proyectos de Generación de Conocimiento PID2021-123462OB-I00University of Texas System
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer's disease (AD)amyloidbiomarkerbloodcerebrospinal fluid (CSF)DNA methylationepigeneticsepigenome‐wide association study (EWAS)neurofilament light (NfL)ptaureplicationYKL‐40

Identifiers

PMID40898416
PMCPMC12405059

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.