Evidence map›Paper›PMID 40898604›Full record

ArticlePlant biotechnology journal2025

Light-Signalling Regulators GmSTF3/4 Enhance Soybean Susceptibility to Cyst Nematodes via Activation of Sugar Transporters.

Bohong Wu, Shuyi Wang, Yuan Zhou, Shuangling Zhao, Wei Zhu, Yin Gao, Guohui Liu, Lijie Chen, Haiyan Fan, Yuanyuan Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bohong WuNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.ORCID https://orcid.org/0009-0000-8722-8638
Shuyi WangNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Yuan ZhouNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Shuangling ZhaoNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Wei ZhuNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Yin GaoNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Guohui LiuNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Lijie ChenNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Haiyan FanNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Yuanyuan WangCollege of Biological Science and Technology, Shenyang Agriculture University, Shenyang, China.
Xiaoyu LiuCollege of Sciences, Shenyang Agriculture University, Shenyang, China.
Ning YangNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Yuxi DuanNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Shoudong WangNational Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, China.
Yuanhu XuanState Key Laboratory and Institute of Elemento-Organic Chemistry, Department of Plant Protection, National Pesticide Engineering Research Center, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, China.ORCID https://orcid.org/0009-0003-3001-7065
Xiaofeng ZhuNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.

Funding

National Key Research and Development Program of China 2023YFD1400400National Natural Science Foundation of China 32272499National Parasitic Resources Center NPRC-2019-194-30
6 · The paper itself

Abstract

Soybean cyst nematode (SCN; Heterodera glycines Ichinohe) is a plant-parasitic nematode that causes substantial yield losses in soybean production. Light signalling is a critical environmental factor that influences photomorphogenesis and carbohydrate metabolism. However, its transcriptional regulation under pathogen-induced stress remains unclear. In this study, the biological function and regulatory mechanism of TGACG-motif binding factor 3/4 (GmSTF3/4), a shoot-to-root mobile protein in soybean (Glycine max), were investigated during H. glycines infection. Evidence was provided that light signalling modulated soybean susceptibility to cyst nematode, marked by light-enhanced nematode infection and upregulation of photoreceptor gene expression post-infection. GmSTF3/4 interacted with CONSTITUTIVE PHOTOMORPHOGENIC1a (GmCOP1a) and mediated its degradation. The nematode was identified to accelerate the shoot-to-root translocation of GmSTF3/4. Phenotypic analysis revealed that GmSTF3/4 promoted nematode development, whereas GmCOP1a exerted an antagonistic effect. Furthermore, the integrated analyses of Cleavage Under Targets and Tagmentation (CUT&Tag) and RNA sequencing (RNA-seq) indicated that GmSTF3/4 bound to the promoters of multiple sugar transporter genes, including GmSWEET8, GmSWEET10b, GmSWEET13d, GmSUC8, and GmERD6-like. The subcellular localization confirmed their plasma membrane targeting, and functional validation in yeast demonstrated the sucrose transport activity of four of these genes. Transient expression assays of five candidate genes during nematode infection supported the positive regulatory role of GmSWEET10b in facilitating nematode infection and development, a result further supported by the Gmsweet10b mutant. Collectively, this study revealed that GmSTF3/4 enhanced soybean susceptibility to cyst nematodes by transcriptionally activating sugar transporter genes, offering a new avenue for SCN-resistance research.

Indexed as

Glycine maxPlant DiseasesPlant ProteinsTylenchoideaAnimalsGene Expression Regulation, PlantLightPlant RootsSignal TransductionPlant ProteinsGmSTF3/4Heterodera glycineslight signallingsoybeansugar transporter

Identifiers

PMID40898604
PMCPMC12665092

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.