Evidence map›Paper›PMID 40898700›Full record

ArticleBasic & clinical pharmacology & toxicology2025

Barriers to and Enablers of Supporting Deprescribing Benzodiazepines in Older Adults: A Survey of European Nonphysician Healthcare Professionals.

Vladyslav Shapoval, Perrine Evrard, François-Xavier Sibille, María López-Toribio, Olivia Dalleur, Carole E Aubert, Lucy Bolt, Vagioula Tsoutsi, Maria Ntafouli, Laura Fernández Maldonado and 9 more

Abstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Vladyslav ShapovalClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.ORCID https://orcid.org/0009-0005-0209-1879
Perrine EvrardClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
François-Xavier SibilleClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
María López-ToribioClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
Olivia DalleurClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
Carole E AubertDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lucy BoltDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Vagioula TsoutsiSleep Research Unit, First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Maria NtafouliSleep Research Unit, First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Laura Fernández MaldonadoHealth and Aging Foundation UAB Autonomous University of Barcelona, Barcelona, Spain.
Ramon MirallesHealth and Aging Foundation UAB Autonomous University of Barcelona, Barcelona, Spain.
Adam WichniakDepartment of Clinical Neurophysiology, Sleep Medicine Center, Institute of Psychiatry and Neurology, Warsaw, Poland.
Katarzyna GustavssonDepartment of Clinical Neurophysiology, Sleep Medicine Center, Institute of Psychiatry and Neurology, Warsaw, Poland.
Torgeir Bruun WyllerDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Enrico CallegariDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Jeremy M GrimshawMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada.
Justin PresseauMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada.
Séverine HenrardClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
Anne SpinewineClinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.

Funding

European Union's Horizon Europe Research and Innovation Program 101057123Fonds de la Recherche Scientifique - FNRSSwiss National Science Foundation PZ00P3_201672/1Swiss State Secretariat for Education, Research and Innovation (SERI) 22.00116
6 · The paper itself

Abstract

Although physicians are primarily responsible for Benzodiazepine Receptor Agonist (BZRA) deprescribing, nonphysician healthcare professionals (HCPs) can support deprescribing. This study explored barriers to and enablers of BZRA deprescribing among nonphysician HCPs. We surveyed 258 HCPs (63.2% nurses) working in hospital settings across six European countries using a questionnaire based on the Theoretical Domain Framework (TDF). Logistic regression assessed associations between TDF domains and both intentions to support and routine engagement in BZRA deprescribing. Major barriers (TDF items with mean < 3) were found in the goals (competing priorities), environmental context and resources (time and staff lack) and social influences (patient reluctance) domains. Five TDF domains were associated with a stronger intention to support deprescribing: social/professional role and identity (OR, 3.08; 95% CI, 1.77-5.46); beliefs about consequences (OR, 1.91; 95% CI, 1.07-3.34); memory, attention and decision processing (OR, 1.80; 95% CI, 1.16-2.82); intention to promote alternatives (OR, 1.63; 95% CI, 1.07-2.49); and reinforcement (OR, 1.57; 95% CI, 1.08-2.29). Knowledge was the only domain associated with routine BZRA deprescribing support (OR, 1.16; 95% CI, 1.06-1.27). Different categories of HCPs face similar major barriers, but barriers vary across HCP categories and countries. Context-specific, targeted interventions may enhance support for BZRA deprescribing.

Indexed as

Attitude of Health PersonnelBenzodiazepinesDeprescriptionsGABA-A Receptor AgonistsHealth PersonnelAdultAgedEuropeFemaleHumansMaleMiddle AgedSurveys and QuestionnairesBenzodiazepinesGABA-A Receptor Agonistsbenzodiazepinesdeprescribingmedication safetynonphysician staffolder adults

Identifiers

PMID40898700
PMCPMC12405739

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.