SynthesisBrain and behavior2025
From Tradition to Innovation: Acupuncture Therapies Targeting Ferroptosis in Neurological Disorders.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From Tradition to Innovation: Acupuncture Therapies Targeting Ferroptosis in Neurological Disorders.Brain and behavior · 2025Pooled it
- Quercetin Activates NRF2/SLC7A11/GPX4 Signaling to Restore Mitochondrial Function Inhibit Ferroptosis Thereby Alleviating Doxorubicin-Induced Cardiotoxicity.Biomolecules · 2026Article
- Acupuncture-Mediated Neuro-Immune Regulation in Musculoskeletal Pain: Mechanisms and Therapeutic Perspectives.Journal of pain research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
introductionAge-related neurodegenerative diseases (NDDs) and stroke represent significant public health challenges due to their high morbidity, mortality, and associated cognitive decline. Current therapeutic strategies often fall short in addressing the complex underlying pathological mechanisms, underscoring the urgent need for innovative treatment approaches. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical factor contributing to neuronal damage in NDDs and stroke.
methodsTo explore how acupuncture-related therapies may modulate ferroptosis and contribute to neuroprotection, we conducted a comprehensive narrative review. A systematic search was performed in PubMed using targeted keywords including "ferroptosis," "interventions" (such as acupuncture, electroacupuncture, and moxibustion), and "diseases" (including age-related neurodegenerative diseases and stroke). The search was restricted to articles published before April 2025 with full-text availability in English.
resultsThis review consolidates recent findings on the potential of acupuncture-related therapies to target ferroptosis in NDDs and stroke. Traditional acupuncture, electroacupuncture (EA), and moxibustion have shown promising neuroprotective effects through multiple mechanisms. Emerging evidence suggests that these interventions can regulate ferroptosis by modulating key molecular pathways involved in iron metabolism, lipid peroxidation, and oxidative stress. These actions are thought to alleviate synaptic dysfunction and slow cognitive decline-processes where ferroptosis plays a central role. Such insights enhance our understanding of how traditional Chinese medicine could influence cognitive outcomes in age-related NDDs and stroke.
conclusionUnderstanding the role of ferroptosis in NDDs and stroke is essential for developing novel therapeutics. Based on current findings, this review proposes future research directions aimed at integrating acupuncture into modern neurotherapeutic frameworks. Combining traditional medicine with contemporary medical approaches offers new opportunities for promoting brain health and improving patient outcomes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.