Evidence map›Paper›PMID 40899212›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2025

[Investigating the protective effect of naringenin on hydrogen peroxide induced oxidative damage of human periodontal ligament stem cells by regulating the forkhead box protein O-1/β-catenin pathway].

Li Zhang, Shiyuan Peng, Feiyang Tang, Jingwei Jian, Shuosheng Yuan, Xiaomei Xu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li ZhangDept. of Orthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
Shiyuan PengDept. of Orthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
Feiyang TangOral and Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, Southwest Medical University, Luzhou 646000, China.
Jingwei JianOral and Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, Southwest Medical University, Luzhou 646000, China.
Shuosheng YuanOral and Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, Southwest Medical University, Luzhou 646000, China.
Xiaomei XuDept. of Orthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInvestigating the protective effect of naringenin (NAR) on the osteogenic potential of human periodontal ligament stem cells (hPDLSCs) under oxidative stress and its related mechanisms.

methodsThe oxidative damage model of hPDLSCs was established using hydrogen peroxide (H

resultsH

conclusionsNAR can enhance the antioxidant capacity of hPDLSCs by activating the FOXO1/β-catenin signaling pathway within hPDLSCs, thereby mitigating oxidative stress damage and alleviating the loss of osteogenic capacity.

Indexed as

beta CateninFlavanonesForkhead Box Protein O1Hydrogen PeroxideOxidative StressPeriodontal LigamentStem CellsAlkaline PhosphataseCell DifferentiationCells, CulturedCore Binding Factor Alpha 1 SubunitHumansOsteocalcinOsteogenesisSignal TransductionAlkaline Phosphatasebeta CateninCore Binding Factor Alpha 1 SubunitFlavanonesForkhead Box Protein O1FOXO1 protein, humanHydrogen PeroxidenaringeninOsteocalcinRUNX2 protein, humanforkhead box protein O-1/β-catenin signaling pathwaynaringeninosteogenic differentiationoxidative stressperiodontal ligament stem cells

Identifiers

PMID40899212
PMCPMC12419831

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.